PMID: 2496522Jan 1, 1989Paper

Immunocytochemical identification of osteogenic bone tumors by osteonectin antibodies

Virchows Archiv. A, Pathological Anatomy and Histopathology
G JundtJ D Termine

Abstract

18 bone-forming tumours and tumour-like lesions were investigated immunocytochemically for the presence of osteonectin. A group of non-bone-forming skeletal tumours (five cartilage-forming tumours, four Ewing sarcomas and five extraskeletal sarcomas) served as controls. The studies showed that osteonectin antibodies react reliably with benign and malignant bone-forming tumours (two cases of fibrous dysplasia, three osteoid osteomas, 13 osteosarcomas). This finding was supported by protein blot studies. Osteonectin is formed by cells which do not yet possess the morphological phenotype of osteoblasts and may be regarded as a "differentiation marker" of the osteoblastic lineage. Only chondroid bone (tissue in which chondrocytes were surrounded by osteoid matrix containing type I and type II collagen) showed a positive reaction. All other primary skeletal tumours and extraskeletal soft tissue tumours were completely negative.

References

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Sep 1, 1985·Calcified Tissue International·Pamela Gehron Robey, John D Termine

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Citations

Jan 12, 2000·The Journal of Pathology·T AignerT Kirchner
Sep 1, 1992·Calcified Tissue International·L MasiF Beghè
Sep 30, 1999·Ultrastructural Pathology·A FranchiM Santucci
Jul 1, 1995·Pathology, Research and Practice·E GrundmannA Roessner
Jun 1, 1991·Human Pathology·T HasegawaS Ishii
Aug 1, 1990·Differentiation; Research in Biological Diversity·R GoralczykJ Schmidt
Aug 15, 1991·Cancer·M Reznik, J Lenelle
Jan 1, 1990·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·J J Sauk
Dec 1, 1992·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Maurice RinguetteFina Liu

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