PMID: 7029527Aug 1, 1981Paper

Immunocytochemical localization of albumin in the secretory apparatus of rat liver parenchymal cells

Proceedings of the National Academy of Sciences of the United States of America
S Yokota, H D Fahimi

Abstract

The localization of albumin was investigated in rat liver, fixed by perfusion, with peroxidase-labeled monospecific antibodies against rat serum albumin purified by affinity chromatography. By light microscopy, albumin is present uniformly in all parenchymal cells with no difference in the intensity of reaction in the different parts of hepatic lobules. By electron microscopy, albumin is localized in the entire secretory apparatus including the rough and smooth endoplasmic reticulum, Golgi complex, and secretory vacuoles. In the rough endoplasmic reticulum, focal negative segments are interposed between positive regions. In the Golgi region, albumin is found both in stacked cisternae and at the trans aspect in the portion called GERL (Golgi-endoplasmic reticulum--lysosome). Whereas albumin and lipoprotein particles are separated in terminal dilatations of the endoplasmic reticulum and in the cisternae on the cis face of the Golgi apparatus, they are usually intermixed in vacuoles of the trans face. Similarly, most secretion vacuoles below the sinusoidal lining contain albumin and lipoprotein particles together, although a few are also found with only one secretory product. These observations suggest that, after synthesis in the...Continue Reading

References

Aug 1, 1976·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M HorikawaT Onoé
Oct 31, 1975·Science·C Lin, J Chang
May 1, 1976·The Journal of Cell Biology·C A AlexanderR J Havel
Aug 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·A B Novikoff
Sep 1, 1977·The Histochemical Journal·A B Novikoff, P M Novikoff
Jan 1, 1978·The Journal of Cell Biology·P M Novikoff, A Yam
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·A B NovikoffP E Thomas
Feb 1, 1977·The Journal of Cell Biology·J P KraehenbuhlJ D Jamieson
May 1, 1966·Analytical Biochemistry·Y H Oh, B E Sanders
Apr 1, 1966·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R C Graham, M J Karnovsky
May 14, 1980·Biochemical and Biophysical Research Communications·G P VlasukF G Walz
Sep 1, 1980·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A B Novikoff
Feb 1, 1964·The Journal of Cell Biology·Y HAMASHIMAA H COONS

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Citations

Jan 1, 1992·Journal of Clinical Laboratory Analysis·S YamadaP K Nakane
Jan 1, 1991·Journal of Electron Microscopy Technique·M Pavelka, A Ellinger
Jul 1, 1990·Cancer Metastasis Reviews·H Rubin
Jun 1, 1994·Cell Biology and Toxicology·C GhoshP Collodi
Feb 1, 1986·Biulleten' eksperimental'noĭ biologii i meditsiny·V N BaranovA I Gusev
Oct 1, 1983·The Histochemical Journal·J A Woods
Feb 17, 2009·Histochemistry and Cell Biology·H Dariush Fahimi
Jul 30, 1985·Biochimica Et Biophysica Acta·J B ParentK Olden
Oct 5, 1987·Biochimica Et Biophysica Acta·J Roth
Jan 1, 1984·Experimental Pathology·A CasuD Cottalasso
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M A SaberD A Shafritz
Oct 1, 1985·The Journal of Cell Biology·L J RizzoloD D Sabatini
Sep 1, 1996·The Journal of Cell Biology·B SönnichsenG Warren
Dec 1, 1996·Journal of Gastroenterology and Hepatology·M IwaiY Ibata
Aug 12, 2009·International Journal of Pharmaceutics·Kenneth J LongmuirRichard T Robertson
Jan 13, 2001·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M GrabenbauerE Baumgart
Apr 15, 2006·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Harry Rubin
Mar 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M BlumrichP Steinberg
Jul 1, 1987·Cell Biochemistry and Function·K R Shroyer, P K Nakane
Jun 1, 1983·The Journal of Experimental Zoology·K Selman, R A Wallace
May 15, 1988·International Journal of Cancer. Journal International Du Cancer·K OgawaS Nagase
Jun 1, 1989·The American Journal of Physiology·E J Blanchette-MackieR O Scow
Aug 7, 2021·Genes·Bhavani P MadakashiraKirsten C Sadler

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