PMID: 2508305Jan 1, 1989Paper

Immunocytochemical localization of BGP in human bones in various developmental stages and pathological conditions

Virchows Archiv. A, Pathological Anatomy and Histopathology
T OhtaS Ishii

Abstract

Bone gamma-carboxyglutamic acid containing protein (BGP) was isolated from human bone and anti-BGP antibody was produced in rabbits. Localization of BGP was investigated immunocytochemically by light and electron microscopy in human bones in various developmental stages and pathological conditions. In the bones of a 12 week fetus, osteoblasts stained strongly in areas of bone formation. However in bones of late fetal stages and in newborns and adults, BGP was localized predominantly in the osteoid and bone matrix in the ossifying front. Osteoblasts and osteocytes also stained positive, but less dominantly than in the early fetus. Electron microscopy showed that BGP was localized in the ER and Golgi cisternae of osteoblasts and osteocytes, and the collagen fibers of the osteoid and bone matrix. The intensity and distribution of staining were not significantly different in osteoporosis and osteoarthritis. These observations indicate that BGP is synthesized by osteoblasts most actively in early fetal life and is then deposited on collagen fibers of the osteoid and bone matrix.

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Citations

Jan 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C S CarlsonM R Adams
Jan 1, 1992·Virchows Archiv. A, Pathological Anatomy and Histopathology·J TakadaM Mori
Jan 1, 1991·Virchows Archiv. A, Pathological Anatomy and Histopathology·T OhtaS Ishii
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·G BoivinP J Meunier
Nov 8, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S ToyosawaT Komori
Jan 1, 1991·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·H SonobeT Goto
Jun 1, 1991·Human Pathology·T HasegawaS Ishii
May 15, 1997·Microscopy Research and Technique·D L GardnerK Oates
May 11, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·D Pavlin, J Gluhak-Heinrich
Mar 26, 1999·Journal of Biomaterials Science. Polymer Edition·H ZreiqatC R Howlett
Jul 1, 1994·Journal of Cellular Biochemistry·E M AardenP J Nijweide

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