PMID: 7519267May 1, 1994Paper

Immunocytochemical localization of bone morphogenetic proteins (BMPs) in salivary gland pleomorphic adenoma

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
S HatakeyamaT Otsu

Abstract

The localization of bone morphogenetic protein (BMP)-1, -2, -3 and transforming growth factor (TGF)-beta in normal salivary gland and pleomorphic adenoma of the salivary gland has been examined immunocytochemically. Tumor cells with BMP immunostaining in pleomorphic adenoma were associated with some solid cellular and tubuloglandular patterns, and with stellate cells in the myxoid area. In addition, in the chondroid area of three pleomorphic adenomas, chondrocyte-like cells were positive for BMPs. It is speculated that BMPs secreted by the tumor cells play a role in the formation of the chondroid component in pleomorphic adenoma by inducing some tumor cells, probably neoplastic myoepithelial cells, to differentiate to chondrocytes by metaplastic change. No tumor cells specifically immunostained with TGF-beta were found. TGF-beta was positive in fibrous and hyalinized stroma. In the submandibular gland, only anti-BMP-1 antibody specifically reacted to apical portions of degenerated serous acinar cells.

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Citations

Nov 2, 2005·Journal of Gastroenterology·Tomotaka AkatsuMasaki Kitajima
Oct 21, 2009·World Journal of Gastroenterology : WJG·Takehiro OkabayashiKazuhiro Hanazaki
Nov 9, 2014·Head and Neck Pathology·Asterios TriantafyllouAlfio Ferlito
Apr 20, 2004·Advances in Anatomic Pathology·Adnan T Savera, Richard J Zarbo
Jul 1, 1997·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Y H GaoA Yamaguchi
Jan 1, 1997·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Y MyokenK Takada
Sep 2, 1998·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·M ZhaoH Nikai
Apr 19, 2011·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Sheng FuYan Jin
Aug 17, 2016·Biochemical Society Transactions·Pawina JiramongkolchaiCharles C Hong
Sep 2, 1998·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·K KusafukaT Takemura

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