Immunocytochemical localization of catecholamine synthesizing enzymes and neuropeptides in area postrema and medial nucleus tractus solitarius of rat brain

The Journal of Comparative Neurology
D M ArmstrongR J Miller

Abstract

The catecholaminergic and peptidergic neurons in the area postrema and adjacent portion of the medial nucleus tractus solitarii (mNTS) were characterized by the immunocytochemical localization of the catecholamine synthesizing enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT) and two neuropeptides, substance P and (Leu5)-enkephalin. The catecholamine synthesizing enzymes TH and DBH, found jointly only in noradrenergic and adrenergic neurons, were localized in cells having a similar morphology and topographical distribution. These cells were located throughout the rostrocaudal and dorsoventral extent of the area postrema, as well as in neurons within the mNTS. The processes showing TH and DBH immunoreactivity appear to form reciprocal connections between the area postrema and mNTS. Phenylethanolamine-N-methyltransferase, the enzymatic marker found only in adrenergic neurons, was detected immunocytochemically in terminals distributed throughout the area postrema and in neuronal perikarya and varicosities within the adjacent mNTS. Like the catecholamine synthesizing enzymes TH and DBH, enkephalin-like immunoreactivity was localized to perikarya, proximal processes ...Continue Reading

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Citations

May 1, 1990·Journal of Electron Microscopy Technique·B E Maley
Nov 1, 2011·Purinergic Signalling·Chiara ManganoBjörn Meister
Jul 8, 1985·Brain Research·D M ArmstrongR D Terry
Dec 15, 1992·European Journal of Pharmacology·Y HikasaS Ogasawara
Feb 1, 1985·Journal of the Autonomic Nervous System·P R Howe
Jun 19, 1992·Brain Research. Developmental Brain Research·J M LuqueA Guillamón
Dec 1, 1994·Brain Research. Molecular Brain Research·J B Boone, D McMillen

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