PMID: 9650885Jul 3, 1998Paper

Immunocytochemical localization of chromogranin A and secretogranin II in female rat gonadotropes

Archives of Histology and Cytology
Tsuyoshi WatanabeY Uchiyama

Abstract

Ultrastructures of pituitary gonadotropes are known to show a prominent sex-related difference: typical male rat gonadotropes contain both large- and small-sized granules, whereas typical female rat gonadotropes appear to exhibit uniformly small-sized granules. Our preceding studies have demonstrated that two representative granins, chromogranin A (CgA) and secretogranin II (SgII), are separately localized to each type of granule in male rat gonadotropes. To clarify whether or not there is a certain relationship between granin proteins and characteristic features of secretory granules in female rat gonadotropes, we examined the expression levels and immunocytochemical localizations of CgA and SgII in the cells. Northern blot and immunoblot analyses demonstrated that both CgA and SgII were synthesized and stored in the female pituitary, although the amount of CgA was much lower in the female than that in the male pituitary. Immunocytochemical observations clarified that gonadotropes in the female pituitary possessed intermediate secretory granules containing both CgA and SgII, in addition to solely CgA-positive and SgII-positive ones. However, secretory granules containing CgA in the female gonadotropes were much smaller in size...Continue Reading

Citations

Feb 13, 2003·Molecular and Cellular Endocrinology·Seok Bean SongKyoon Eon Kim
Nov 20, 2002·Annals of the New York Academy of Sciences·Taeyoon KimY Peng Loh
Sep 11, 2007·Archives of Histology and Cytology·Katsuyuki KitaharaTsuyoshi Watanabe

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