PMID: 2493969Jan 1, 1989Paper

Immunocytochemical localization of cytochrome P-450scc in cultured rat oligodendrocytes

Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie
I Jung-TestasE E Baulieu

Abstract

Primary cultures of glial cells from newborn rat forebrain were tested after 3 to 4 weeks. Oligodendrocytes and astrocytes were characterized by immunofluorescence with monoclonal antibodies to galactocerebroside and glial fibrillary acidic protein, respectively. The cytoplasm of oligodendrocytes was specifically and intensely immunostained with monospecific polyclonal antibodies to the cytochrome P-450scc involved in the synthesis of pregnenolone from cholesterol. This observation brings additional support to the concept of "neurosteroids".

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