Immunocytochemical localization of stanniocalcin cells in the rat kidney

Endocrinology
M HaddadG F Wagner

Abstract

Stanniocalcin (STC) is a polypeptide hormone that was first discovered in fishes, where it functions as a regulator of calcium and phosphate homoeostasis. Recently, complementary DNAs encoding human STC (hSTC) have been characterized, and recombinant hSTC has been synthesized in a bacterial expression system. In preliminary studies, STC-immunoreactive cells have already been identified in human kidney tubules with antibodies to recombinant hSTC. The purpose of this study was to map the overall spatial distribution of STC cells in mammalian kidney, using the rat as a model system. Immunocytochemistry was performed on fixed sections of rat kidney tissue using hSTC antiserum in conjunction with fluorescein isothiocyanate-conjugated second antibodies. STC-immunoreactive cells were found in cortical thick ascending limb, in macula densa, in distal convoluted tubules, and in the cortical and medullary collecting ducts. All cortical thick ascending limb cells contained immunoreactive STC. Most distal convoluted tubules cells contained STC, and these were identified as principal cells. The distribution of STC cells in cortical and medullary collecting ducts also corresponded closely to the known frequently of principle cells in these s...Continue Reading

Citations

Mar 19, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Yuji YoshikoNorihiko Maeda
Aug 18, 1999·Electrophoresis·R A WorthingtonJ A Barden
Feb 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G F WagnerJ L Renfro
Aug 12, 2006·Journal of Experimental Zoology. Part A, Comparative Experimental Biology·Graham F Wagner, Gabriel E Dimattia
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Aug 31, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jason M MoreauJohn Ciriello

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