Immunocytochemical localization of the neural cell adhesion molecules L1, N-CAM, and J1 in Pacinian corpuscles of the mouse during development, in the adult and during regeneration.

Journal of Neurocytology
C NolteR. Martini

Abstract

The immunocytochemical localization of the neural cell adhesion molecules L1, N-CAM and J1/tenascin was investigated by light and electron microscopical techniques in murine Pacinian corpuscles during development, in the adult and in the regenerating state. In adult corpuscles, L1 was present only at contact sites between the sensory axon and inner core lamellae. From birth, the earliest stage tested, until day 7, L1 was additionally expressed on lamellar processes of the inner core cells. N-CAM was expressed in developing and adult corpuscles on lamellae and somata of the inner and outer core cells at their contact sites but was hardly detectable at contact sites between axolemma and inner core lamellae. J1/tenascin was found only in association with the extracellular material of the inner core, especially with the two radial clefts and the boundary space between inner and outer core. In developing corpuscles, J1/tenascin became detectable on extracellular material with the onset of inner core differentiation at approximately day 2. After transection or crush of the sciatic nerve, L1 disappeared from the corpuscles but reappeared with regrowing axons at contact sites between axonal membranes and inner core cells. At any regene...Continue Reading

References

Feb 1, 1978·The Biochemical Journal·M L Groves, R Greenberg
Feb 1, 1978·Journal of Neurocytology·J Zelená
Jan 1, 1976·Progress in Brain Research·L Malinovský
Sep 1, 1986·The Journal of Cell Biology·J K DaniloffG M Edelman
Jan 12, 1988·Brain Research·J Zelená, I Jirmanová
Oct 1, 1987·Archivum Histologicum Japonicum = Nihon Soshikigaku Kiroku·C IdeB L Munger
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J Covault, J R Sanes
Nov 1, 1974·Journal of Neurocytology·V Chan-PalayS M Billings-Gagliardi
Apr 1, 1974·American Journal of Surgery·A H HermanD C Nabseth
Jun 1, 1973·Journal of Neurocytology·P S Spencer, H H Schaumburg
Oct 1, 1984·Journal of Neurocytology·J Zelená
Jan 1, 1983·Cold Spring Harbor Symposia on Quantitative Biology·C GoridisJ Finne
Jan 1, 1982·Cell and Tissue Research·J Zelená
May 25, 1957·The Journal of Biophysical and Biochemical Cytology·D C PEASE, T A QUILLIAM

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Citations

Apr 1, 1997·Critical Reviews in Oncology/hematology·G Vollmer
Feb 1, 1990·The European Journal of Neuroscience·Thomas FahrigMelitta Schachner
Nov 9, 2004·Experimental Neurology·Chris M NicholsSusan E Mackinnon
Jun 23, 2004·Trends in Immunology·Bert A 't Hart, Yvette van Kooyk
Jun 6, 2009·Acta Histochemica Et Cytochemica·Takahiro Naka, Satoshi Yokose
May 1, 1991·The British Journal of Psychiatry : the Journal of Mental Science·P Jones, R M Murray
Dec 1, 1992·Histochemistry·N KawakitaC Ide
Jul 1, 1996·Microscopy Research and Technique·P Dubový, H Aldskogius
Jun 1, 1996·Neuroscience Research·C Ide

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