Immunocytochemical localization of tyrosine hydroxylase in the human fetal nervous system

The Journal of Comparative Neurology
V M PickelA Hervonen

Abstract

The peroxidase-antiperoxidase (PAP) technique is used to determine the cellular localization of tyrosine hydroxylase in the human fetal nervous system. Antiserum to trypsin-treated tyrosine hydroxylase from the bovine adrenal medulla can be detected immunocytochemically in peripheral sympathetic neurons in the 8-mm (5-week) fetus, but can not be detected in the central nervous system until later stages of development. The cytological features and distribution of the neuronal perikarya and processes labeled for the enzyme are similar to those of the catecholaminergic neurons previously identified by histofluorescence. These findings indicate that specific neurons in the human fetus have at least one of the enzymes necessary for the biosynthesis of catecholamines and that cross-species reactivity exists between antiserum produced to the bovine tyrosine hydroxylase and human tissues.

References

Jan 1, 1977·International Review of Neurobiology·J T Coyle
Apr 13, 1979·Brain Research·J PearsonL Brandeis
Jan 1, 1975·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·V M PickelD J Reis
Oct 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·T H JohD Reis
Jan 1, 1972·Zeitschrift Für Anatomie Und Entwicklungsgeschichte·A Hervonen, L Kanerva
Jan 1, 1972·Zeitschrift Für Anatomie Und Entwicklungsgeschichte·L Olson, A Seiger
Aug 30, 1973·Zeitschrift Für Anatomie Und Entwicklungsgeschichte·A Seiger, L Olson
Jun 1, 1970·The Journal of Comparative Neurology·J B Angevine

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Citations

May 14, 1998·The Journal of Comparative Neurology·L Puelles, C Verney
Jul 24, 1992·Brain Research. Developmental Brain Research·J H KordowerP Rakic
Sep 17, 1993·Brain Research. Developmental Brain Research·E SundströmA Seiger
Mar 19, 1993·Brain Research. Developmental Brain Research·M T Panayotacopoulou, D F Swaab
Jan 1, 1984·Neurobiology of Aging·R G StrubleD L Price
Apr 1, 1983·Brain Research Bulletin·J A Wallace, J M Lauder
Jan 1, 1983·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·P Helén, A Hervonen
Jan 1, 1986·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·N Hagino, K Inoue
Apr 1, 1996·Journal of Chemical Neuroanatomy·K KitahamaJ Pearson
Dec 25, 2003·Early Human Development·Toshiko SawaguchiAndre Kahn
Jul 10, 2003·Life Sciences·Dietrich E LorkeDavid T Yew
Dec 13, 2000·Brain Research. Brain Research Reviews·D O Frost, J L Cadet
Oct 1, 1996·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·K Sailaja, G Gopinath
Feb 9, 2008·Medicinski pregled·Sinisa S BabovićLjubica Stojsić-Dzunja
Jul 31, 1999·Pediatric Neurology·Y OzawaS Takashima
Sep 1, 1991·Experimental Neurology·T B FreemanJ H Kordower
Sep 21, 2010·Experimental Neurology·T B FreemanS B Dunnett
Feb 18, 2017·International Journal of Molecular Sciences·Nina VardjanRobert Zorec
May 24, 2007·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Urs MeyerJoram Feldon
Mar 3, 1997·The Journal of Comparative Neurology·I AubertB Bloch
Jun 1, 2005·The Journal of Comparative Neurology·Bret A MorrowJohn D Elsworth
Sep 25, 1995·The Journal of Comparative Neurology·C BranaB Bloch
Jan 22, 1990·The Journal of Comparative Neurology·J H Kordower, P Rakic

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