PMID: 9178803May 16, 1997Paper

Immunocytochemical monitoring of micrometastatic disease: reduction of prostate cancer cells in bone marrow by androgen deprivation

International Journal of Cancer. Journal International Du Cancer
Klaus PantelM W Köllermann

Abstract

Occult dissemination of tumor cells mainly determines the prognosis of patients with primary prostate cancer. The effect of androgen deprivation on micrometastatic tumor cells in these patients is currently unknown. We therefore used an immunocytochemical assay with monoclonal antibodies (MAbs) directed against epithelial cytoskeleton proteins (i.e., cytokeratins) to monitor the concentration of isolated tumor cells in the bone marrow of 36 prostate cancer patients (stage C), who underwent hormonal androgen deprivation with Flutamide and Leuprorelin acetate. Tumor cells in cytologic bone marrow preparations were detected using an assay that employed the MAb CK2 directed against cytokeratin (CK) 18 and the alkaline anti-alkaline phosphatase staining method. Prior to therapy, we detected between 1 and 38 CK-positive cells per sample of 2 x 10(6) nucleated cells in 21 patients, while the remaining 15 patients displayed tumor-free marrow samples. There was no significant correlation between the concentration of CK-positive cells and the volume of hypo-echogenic lesions as an indicator of the primary tumor volume or the serum level of prostate-specific antigen (PSA). After androgen deprivation, 20 of the 21 initially positive patien...Continue Reading

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Citations

Aug 5, 2011·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Nigel P MurrayPablo Tapia
Jun 27, 2009·Cancer Investigation·Stephan BraunChristian Marth
Mar 20, 2002·Clinical Breast Cancer·K Pantel, S Braun
May 31, 2008·Surgical Oncology·Pauline Athanassiadou, Dimitra Grapsa
Dec 6, 2007·The Breast : Official Journal of the European Society of Mastology·Stephan BraunChristian Marth
Jan 6, 2007·International Journal of Cancer. Journal International Du Cancer·Heidi SchwarzenbachKlaus Pantel
Aug 21, 2008·International Journal of Cancer. Journal International Du Cancer·Sabine RiethdorfKlaus Pantel
Jan 19, 2007·International Journal of Cancer. Journal International Du Cancer·Arne BergGunnar Kvalheim
Apr 6, 2016·Cancer Biology & Therapy·Jussuf T KaifiKevin F Staveley-O'Carroll
Jul 7, 1999·Journal of the National Cancer Institute·K PantelO Fodstad
Sep 17, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jens KöllermannKlaus Pantel
Jan 7, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S BraunK Pantel
Mar 7, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S BraunF Hepp
Aug 14, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Catherine Alix-PanabièresKlaus Pantel

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