Immunocytochemical reactivity of breast cancer tissue with antibodies to neuron-specific enolase and an adenocarcinoma-associated glycolipid antigen.

Virchows Archiv. A, Pathological Anatomy and Histopathology
H Ingelman-SundbergA Hjerpe

Abstract

The immunocytochemical reactivity of breast cancers to antibodies raised against neuron-specific enolase (NSE), carcinoembryonic antigen (CEA) and an adenocarcinoma-associated glycolipid antigen (IR-14) was studied in relation to the long-term outcome of the neoplastic disease. The patients whose tumours exhibited reactivity with the IR-14 and anti-NSE antibodies had a considerably better 5-year and long-term survival than those without such reactivity. Assessment of DNA-ploidy of the tumour cells was also relevant for long-term prognosis, immunohistochemistry giving additional prognostic information among aneuploid tumours. Reactivity with polyclonal CEA antibodies was of no prognostic value. It is suggested that tumours carrying the IR-14 reactive epitope, which was originally isolated from circulating antigen-antibody complexes, might evoke a favourable immune response and thus improve the survival of the patient.

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Citations

Dec 9, 2003·The Breast : Official Journal of the European Society of Mastology·Osman ZekiogluHatice Bayramoglu
Dec 1, 1994·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·P Kiriakogiani-PsaropoulouN Pavlidis
Jan 28, 2006·FEMS Microbiology Reviews·James P BurnieRuth C Matthews
Apr 1, 1989·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·L de Repentigny

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