Immunocytochemical staining of cytologic specimens. How helpful is it?

American Journal of Clinical Pathology
P W ShieldR G Wright

Abstract

The contribution of immunocytochemical (ICC) staining to the diagnosis of a range of cytologic specimens reported over a 20-month period was retrospectively assessed. A total of 194 cases (1.6% of total workload) were stained for diagnostic purposes in this period. Immunocytochemical staining was determined to be helpful in 75.8% of cases. In body fluid cases (105), staining was most often performed to assist with the discrimination of mesothelial cells and metastatic malignancy. Immunocytochemical staining was helpful in 82% of fluid specimens, with the preliminary diagnosis confirmed in 64%, refined in 8%, and revised in 10% of cases. In fine-needle aspiration (FNA) specimens, staining was helpful in 69%, resulting in a refinement of diagnosis in 55%, and confirming the preliminary diagnosis in 14%. The preliminary diagnosis was revised in a single FNA case. Immunocytochemical staining was particularly valuable in assisting the subclassification of poorly differentiated malignancies. A more precise diagnosis was possible following consideration of ICC results in 68% of cases with a preliminary diagnosis of poorly differentiated malignancy. Immunocytochemical staining was also helpful in identifying the primary site of metasta...Continue Reading

Citations

Sep 4, 1999·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·C SchuhmacherH Höfler
Jul 23, 1999·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·D ChappardM F Baslé
May 29, 2004·Cytopathology : Official Journal of the British Society for Clinical Cytology·P Shield
Mar 13, 2020·Cancer Cytopathology·Safa AlshaikhStefan E Pambuccian
Jul 17, 2008·Cytopathology : Official Journal of the British Society for Clinical Cytology·R JalalS Pervez
Nov 24, 2018·Diagnostic Cytopathology·Lester J LayfieldRobert L Schmidt
Oct 6, 2007·Cytopathology : Official Journal of the British Society for Clinical Cytology·P W Shield, K Koivurinne
Feb 19, 2000·The American Journal of Surgical Pathology·M BenevoloM Mottolese
Mar 11, 2021·Journal of Pediatric and Adolescent Gynecology·Marta BaczewskaWiktor Bortnik

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