Jul 25, 1997

Immunocytochemical studies of neurotrophins in cerebral motor cortex in Amyotrophic Lateral Sclerosis

Brain Research
R M DuberleyN J Cairns


Neurotrophin-like immunoreactivity was studied in post-mortem motor cerebral cortex from patients with Amyotrophic Lateral Sclerosis (ALS) and controls. Neurotrophin-4/5 immunoreactivity was seen in small-(12-25 microm), medium-(26-39 microm), and large-(> 40 microm), neurones, neurotrophin-3 was seen in medium and small neurones, while brain-derived neurotrophic factor was restricted to small neurones. No difference in number or intensity of immunostained neurones was found between ALS and controls.

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Mentioned in this Paper

Brain-Derived Neurotrophic Factor
Amyotrophic Lateral Sclerosis
Neurotrophin 5
Neurite Outgrowth Factors
Amyotrophic Lateral Sclerosis, Guam Form
Neuroprotective Effect
Motor Cortex
Neurotrophin 3

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