Abstract
The expression of epidermal growth factor receptor (EGFr) and transforming growth factor alpha (TGF-alpha) was compared with the presence of "squamous differentiation" (SD) visualized in various histotypes of endometrial carcinoma by using a panel of monoclonal antibodies. The results of the current study demonstrate that EGFr and TGF-alpha are present in routinely processed endometrial carcinoma. The highest positive EGFr and TGF-alpha expression was seen in the group of adenocarcinomas with SD. The more intense EGFr and TGF-alpha immunoreactivity was observed in "squamous" foci both in adenoacanthomas (AA) and in adenosquamous carcinomas (AS). These EGFr- and TGF-alpha-positive squamous areas prevalently displayed a "stratification-related" cytokeratin (CK) immunoprofile characterized by the expression of CKs 1, 4, 5, 10, 13, 14, and 16. No correlation was found between EGFr- and TGF-alpha-positive status and depth of myometrial invasion or surgical stage. These results clearly demonstrate that EGFr and TGF-alpha expression is related remarkably to endometrial carcinoma with "squamous" areas both morphologically and immunophenotypically. This specific association leads us to suggest that EGFr and TGF-alpha expression in endom...Continue Reading
References
Jan 1, 1979·Annual Review of Biochemistry·G Carpenter, S Cohen
Oct 1, 1976·The Journal of Cell Biology·G Carpenter, S Cohen
May 1, 1992·British Journal of Obstetrics and Gynaecology·A PrenticeC H Horne
Oct 1, 1991·Human Pathology·R MollB Czernobilsky
Jan 1, 1991·Annals of the New York Academy of Sciences·L J MurphyB Bhavnani
Nov 1, 1990·Cancer·R K ReynoldsK M Menon
Aug 1, 1986·The American Journal of Surgical Pathology·D J DabbsH T Norris
Nov 1, 1989·American Journal of Obstetrics and Gynecology·A BerchuckK S McCarty
Jan 1, 1989·Journal of Cancer Research and Clinical Oncology·T BauknechtA Pfleiderer
Jan 1, 1989·Gynecologic and Obstetric Investigation·F BattagliaS Mancuso
May 1, 1986·Experimental Cell Research·G Carpenter, J G Zendegui
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·E FinziS A Aaronson
Mar 1, 1988·Biology of Reproduction·T H LinG M Stancel
Feb 1, 1988·Endocrinologia Japonica·Y Taketani, M Mizuno
Jan 1, 1970·Histochemie. Histochemistry. Histochimie·H PuchtlerH M Conner
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Jan 1, 1982·Journal of Cellular Biochemistry·M D WaterfieldB Ozanne
Sep 1, 1984·Pathology, Research and Practice·B CzernobilskyP Hohlweg-Majert
Apr 1, 1993·Histochemistry·D SantiniG N Martinelli
Jan 1, 1993·Virchows Archiv. A, Pathological Anatomy and Histopathology·T J LiJ B Matthews
Jul 15, 1993·Cancer·R J LelleK M Menon
Jul 1, 1993·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·H C NyholmB Ottesen
Citations
Jul 1, 1996·The Australian and New Zealand Journal of Surgery·C S LeeG Boag
Mar 17, 2007·Pathology·Annie N Y Cheung
May 8, 1998·Gynecologic Oncology·R FujiwakiK Miyazaki
Jun 21, 1996·International Journal of Cancer. Journal International Du Cancer·A DellasF Gudat
Aug 1, 1996·Cancer·A J GuidiL F Brown
Mar 1, 1997·The Journal of Clinical Endocrinology and Metabolism·J YavelowT H Finlay
Mar 1, 1996·The Journal of Urology·J W MoulC K Ho
Aug 11, 2017·Cancer Science·Kazuhiro OkumuraYuichi Wakabayashi