PMID: 6106615Jun 1, 1980Paper

Immunocytochemical study of the endocrine pancreas in the rat during normal pregnancy and during experimental diabetic pregnancy

Diabetologia
F A Van AsscheL Aerts

Abstract

The distribution of different celltypes (A, B, D and PP cells) of the endocrine pancreas was studied in both the normal and in the experimental diabetic non-pregnant and pregnant rat. In the normal rat the head (juxta duodenal part) of the pancreas contained more PP cells than the tail (12.5 +/- 1.1 versus 5.2 +/- 2.2) but fewer glucagon cells (19.0 +/- 3.5 versus 14.3 +/- 3.6). This difference disappeared during pregnancy, when the total B cell mass increased (2.05 versus 0.82). In the diabetic rat no difference was found in the number of endocrine cells between the tail and the juxta duodenal part of the pancreas. Unlike the non-diabetic rat, the number of B cells did not increase in the pancreas of the pregnant diabetic rat. An absolute increase in the number of glucagon (A) cells was demonstrated in the islets of the pregnant diabetic rat as compared to the non-diabetic rat (35 versus 21.2).

Citations

Dec 1, 1990·Diabetes/metabolism Reviews·L AertsF A Van Assche
Jul 8, 1985·Life Sciences·H S Bender, W R Chickering
Apr 1, 1995·Physiology & Behavior·T R KoiterG A Schuiling
Nov 5, 1997·Diabetes Research and Clinical Practice·L AertsF A Van Assche
Jan 24, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·Martin KöhlerPer-Olof Berggren
Jul 1, 1995·The Proceedings of the Nutrition Society·S DahriJ J Hoet
Oct 13, 2009·Diabetes, Obesity & Metabolism·C DemetercoF Levine
Nov 13, 2013·The Journal of Clinical Investigation·Josie X ZhouAnil Bhushan
Aug 17, 2011·Diabetes Management·Sara ErnstAdolfo Garcia-Ocaña
Jan 1, 1989·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·C L Gomez DummJ J Gagliardino
Dec 30, 2014·Molecular Aspects of Medicine·Emilyn U AlejandroErnesto Bernal-Mizrachi
Jan 26, 2002·British Medical Bulletin·F A Van AsscheL Aerts
Sep 27, 2005·Physiological Reviews·Luc Bouwens, Ilse Rooman
Mar 25, 2009·Endocrinology·Robert L Sorenson, Todd C Brelje

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