PMID: 7523336Jun 1, 1994Paper

Immunocytochemical study of tyrosine hydroxylase and dopamine beta-hydroxylase immunoreactivities in the rat pancreas

Histochemistry
Y OomoriK Ono

Abstract

An immunohistochemical and immunoelectron microscopic study was used to demonstrate tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) immunoreactivities in the rat pancreas. Small TH immunoreactive cells were found in close contact with large TH immunonegative ganglion cells among the exocrine glands and were occasionally found in some islets. Some of these TH immunoreactive cells were also DBH immunopositive. The immunoreaction product was seen diffusely in the cytoplasm and in the granule cores of TH immunoreactive cells. All intra-pancreatic ganglion cells were immunoreactive for DBH, but not for TH. The TH immunoreactive cells were identified as small intensely fluorescent (SIF) cells due to their localization and morphological characteristics and showed no insulin, glucagon, somatostatin or pancreatic polypeptide immunoreactivities. These results indicate that SIF cells may release dopamine or noradrenaline to adequate stimuli while the intra-pancreatic ganglion cells with only DBH may not synthesize catecholamines in a normal biosynthetic pathway. TH immunoreactive nerve bundles without varicosities and fibers with varicosities, associated or unassociated with blood vessels, were found in both the exocrine and...Continue Reading

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Citations

Jul 4, 1997·Journal of Chromatography. B, Biomedical Sciences and Applications·D HooperG Eisenhofer
Sep 17, 1996·Proceedings of the National Academy of Sciences of the United States of America·E MezeyB J Hoffman
Nov 23, 2006·Autonomic Neuroscience : Basic & Clinical·Jeffrey A LoveTina G Smith
Jan 25, 2005·Autonomic Neuroscience : Basic & Clinical·Eunyoung YiJeffrey A Love
Apr 11, 2007·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Marcin Bartłomiej Arciszewski, Anna Zacharko-Siembida
Jun 26, 2007·Acta Biologica Hungarica·M B Arciszewski, Anna Zacharko-Siembida
Mar 25, 2011·Journal of Neurophysiology·Yeechan WuMing-Yuan Min
Nov 7, 2001·BMC Endocrine Disorders·Maria I Borelli, Juan J Gagliardino
Nov 21, 2020·Annals of Clinical and Translational Neurology·Guillaume LamotteDavid S Goldstein
Mar 20, 2021·The Journal of Biological Chemistry·Katsuya MiyajimaHiroshi Ichinose
Mar 24, 2021·Scientific Reports·Martha Campbell-ThompsonMark A Atkinson

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