Immunocytochemically defined interneuron populations in the hippocampus of mouse strains used in transgenic technology

Hippocampus
Ferenc MátyásA I Gulyás

Abstract

Transgenic mice are overtaking the role of model animals in neuroscience. They are used in developmental, anatomical, and physiological as well as experimental neurology. However, most results on the organization of the nervous system derive from the rat. The rat hippocampus and its neuronal elements have been thoroughly investigated, revealing remarkable functional and morphological diversity and specificity among hippocampal interneurons. Our aim was to examine the properties of distinct hippocampal interneuron populations, i.e., those immunoreactive for calcium-binding proteins (parvalbumin, calbindin, and calretinin), neuropeptides (cholecystokinin, neuropeptide Y, somatostatin, vasoactive intestinal polypeptide), and certain receptors (metabotropic glutamate receptor 1alpha, cannabinoid receptor type 1) in four strains of mice widely used in transgenic technology, and to compare their properties to those in the rat. Our data indicate that the distribution as well as the dendritic and axonal arborization of mouse interneurons immunoreactive for the different markers was identical in the examined mouse strains, and in most respects are similar to the features found in the rat. The postsynaptic targets of neurons terminating ...Continue Reading

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Citations

Jan 1, 1996·Hippocampus·T F Freund, G Buzsáki
Dec 8, 2004·Proceedings of the National Academy of Sciences of the United States of America·Mohsin RazaRobert J DeLorenzo
Sep 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Kang ZhengBai Lu
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Jul 2, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Megan S WyethCarolyn R Houser
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