Immunocytological evidence of motilin- and secretin-containing cells in the human fetal gastro-entero-pancreatic system

Cell and Tissue Research
P LeduqueP M Dubois

Abstract

The ontogeny and distribution of immunoreactive motilin and secretin were studied in the gastro-entero-pancreatic (GEP) system of human fetuses, aged 5--24 weeks, using an indirect immunocytochemical method. Several controls to check for the specificity of the immunoperoxidase staining were performed. The first motilin- and secretin-containing cells were observed in the duodenal and jejunal mucosa in fetuses at a gestational age of 16 weeks. These immunoreactive cells were located in the glands of Lieberkühn and in the villi. No immunoreactive cells were present in the oxyntic and pyloric mucosa, ileum, colon and endocrine pancreas. These observations indicate that the motilin- and secretin-containing cells detected by our antisera appear (i) in the same organs of the fetus where they are also detectable in the adult, and (ii) after the completion of histogenesis of the gastro-entero-pancreatic (GEP) system.

Citations

Feb 1, 1983·Regulatory Peptides·J A ChayvialleP M Dubois
Nov 28, 1985·Regulatory Peptides·H SuzukiS R Bloom
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·L DeltourD Bucchini
May 25, 2005·Pediatrics International : Official Journal of the Japan Pediatric Society·Toshiya NishikuboMasanori Fujimura
Mar 1, 1990·Endocrine Pathology·Anne E Bishop, Julia M Polak

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