PMID: 6965479Jan 1, 1980Paper

Immunocytological studies in a case of Bruton's disease

European Journal of Pediatrics
A StatzE Gladtke

Abstract

Immunopathological findings in a case with infantile X-linked agamma globulinemia (Bruton's disease) are reported and compared to similar data from two cousins of the patient. Besides a severe decrease in B-lymphocytes in blood and lymph node, residual B-cells showed an almost total defect in Ig surface receptor expression. In addition, there was an unusual lymphocyte population which apparently exhibited E-rosette formation (i.e. T-cell characteristics) and phagocytosis. The data suggest that in Bruton's disease there may be a disturbance of the T-cell system besides the well known B-cell deficiency.

References

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Citations

Aug 1, 1989·American Journal of Medical Genetics·M B KrawinkelJ Schaub

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