ImmunoCyt/uCyt+ improves the sensitivity of urine cytology in patients followed for urothelial carcinoma

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Bernard TêtuYves Fradet

Abstract

ImmunoCyt/uCyt is a fluorescent test combining three monoclonal antibodies. In this study, it has been tested as a complement to cytology in the detection of urothelial carcinoma in urine. It has been performed simultaneously with standard cytology and cystoscopy on 870 urine analyses from one hospital. In 136 cases, one or more bladder tumors were found. Overall sensitivity of cytology, ImmunoCyt/uCyt and combined analyses reached 29, 74 and 84%, respectively, and overall specificity was 98, 62 and 61%. The negative predictive value of cytology, ImmunoCyt/uCyt and both analyses was 88, 93 and 95%, respectively, and the positive predictive value was 70, 26 and 29%. The sensitivity of cytology for low malignant potential neoplasms, low- and high-grade papillary carcinomas was 6, 18 and 53%, while it reached 71, 79 and 93% when combined with ImmunoCyt/uCyt. The sensitivity of cytology for stages Ta, T1, T2 and over and Tis tumors was 12, 67, 47 and 50%, while it reached 78, 83, 79 and 100% when combined with ImmunoCyt/uCyt. In the absence of tumor on cystoscopy but with positive ImmunoCyt/uCyt, 18% of patients developed a tumor, 2-6 months later. Of the 109 cases diagnosed as suspicious for malignancy by cytology, a tumor was pre...Continue Reading

References

Jul 2, 1998·The Journal of Urology·D S StampferW S McDougal
Aug 28, 1998·The Journal of Urology·J P SteinR J Cote
Jan 23, 1999·The Journal of Urology·S RamakumarD J O'Kane
Apr 21, 1999·The Journal of Urology·C MianM Marberger
Mar 21, 2001·The Journal of Urology·V B Lokeshwar, M S Soloway
Apr 18, 2001·Urology·J L Gutiérrez BañosB M García
Oct 26, 2001·Scandinavian Journal of Urology and Nephrology·H Olsson, B Zackrisson
Feb 11, 2003·The Journal of Urology·Christian PfisterJean-Jacques Rambeaud
Jun 17, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Eric PiatonUNKNOWN French Prospective Multicenter Study
May 12, 2004·Urology·Michele LoddeArmin Pycha

❮ Previous
Next ❯

Citations

Mar 13, 2013·Molecular Diagnosis & Therapy·Steve GoodisonVirginia Urquidi
Jun 6, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Bernard Têtu
Oct 9, 2008·Annual Review of Pathology·Anirban P Mitra, Richard J Cote
Sep 21, 2013·Biomarkers in Medicine·Charles J RosserSteve Goodison
May 1, 2009·Expert Opinion on Medical Diagnostics·Brian Keith McNeil, Robert H Getzenberg
Oct 23, 2012·European Urology·Mahul B AminUNKNOWN International Consultation on Urologic Disease-European Association of Urology Consultation on Bladder Cancer 2012
Jun 13, 2009·Lancet·Donald S KaufmanAdam S Feldman
Feb 27, 2007·Urology·Motoo ArakiMark S Soloway
Nov 29, 2015·The Urologic Clinics of North America·Aurélie MbeutchaShahrokh F Shariat
Dec 2, 2006·Urologic Oncology·Vinata B Lokeshwar, Marie G Selzer
Sep 1, 2008·Proteomics. Clinical Applications·Sulma I Mohammed, Munazzah Rahman
Dec 1, 2010·Cytopathology : Official Journal of the British Society for Clinical Cytology·I SternbergI Leibovitch
Mar 15, 2006·Urology·Shomik Sengupta, Michael L Blute
Apr 18, 2015·The Urologic Clinics of North America·Ilaria LuccaShahrokh F Shariat
Apr 4, 2015·Hematology/oncology Clinics of North America·Maxine Sun, Quoc-Dien Trinh
Dec 6, 2016·International Neurourology Journal·Hong-Tao LiGangning Liang
Dec 13, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter C BlackColin P Dinney
Jan 15, 2014·Urologia·Fabrizio Dal MoroFiliberto Zattoni
Jan 12, 2010·Nature Reviews. Urology·Anirban P Mitra, Richard J Cote
Jul 1, 2008·Expert Review of Anticancer Therapy·Samir P Shirodkar, Vinata B Lokeshwar
Mar 7, 2017·Turkish Journal of Medical Sciences·Emrah YürükAhmet Yaser Müslümanoğlu
Dec 5, 2019·Expert Review of Molecular Diagnostics·Antonio Lopez-BeltranRodolfo Montironi
Jul 25, 2012·Current Opinion in Urology·Anirban P MitraRichard J Cote
Apr 21, 2018·Journal of Cancer Research and Clinical Oncology·Susanne DeiningerT Todenhöfer
Aug 3, 2018·BioMed Research International·B SzymańskaA Długosz
Nov 23, 2020·Journal of the American Society of Cytopathology : JASC·Patrick J McIntireGüliz A Barkan
Oct 27, 2015·Annals of Internal Medicine·Roger ChouShelley Selph

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.