Immunodepletive anti-alpha/beta-TCR antibody in transplantation of composite tissue allografts: Cleveland Clinic research experience

Immunotherapy
Maria Siemionow, Aleksandra Klimczak

Abstract

The immunologic characteristics of composite tissue allografts (CTA), which contain skin, lymphoid elements and bone with bone marrow, raise new challenges for transplant immunologists. Owing to the heterogeneity of transplanted tissues in limb or face transplant models, researchers are focusing on the new tolerance-inducing strategies facilitating CTA acceptance. A number of immunosuppressive protocols have been designed to develop tolerance in experimental models; however, only a few protocols have been introduced to clinical transplantation. In this review, based on own experiences, we discuss the major strategies for tolerance induction in limb and face allograft models in experimental studies. This review is focused on tolerance induction strategies by establishment of donor-specific chimerism using different immunomodulatory protocols, including nonselective T-cell depletion with polyclonal antibody antilymphocyte serum and selective inhibition of alphabeta-T-cell receptors on the alloreactive T cells.

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Citations

May 11, 2021·Archivum Immunologiae Et Therapiae Experimentalis·Joanna CwykielMaria Siemionow
Oct 12, 2021·Archivum Immunologiae Et Therapiae Experimentalis·Arkadiusz JundziłłMaria Siemionow

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Methods Mentioned

BETA
immunodepletion
biopsy
flow cytometry

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