PMID: 45126Jan 1, 1979

Immunodepression and the course of infection of a chronic Trypanosoma brucei infection in mice

Parasite Immunology
K M Hudson, R J Terry

Abstract

The relationships between course of infection, antigenic variation, and immunodepression of antibody responses to heterologous antigens have been investigated in mice chronically infected with Trypanosoma brucei. T. brucei Brunel University Trypanosomiasis (BUT) 64 produces a fluctuating parasitaemia lasting about 80 days and ending fatally. It is demonstrated that recurring peaks of parasitaemia are associated with the appearance of new variant antigenic types. At 21 and 31 days of infection, IgG responses to the heterologous antigen, sheep red blood cells (SRBC), are absent and IgM responses are less than 5% of normal. When a single dose of cyclophosphamide (300 mg/Kg) was injected into mice on day 31 of infection, the parasitaemia rose sharply in an uncontrolled fashion and the treated mice died in about 10 days. Cyclophosphamide, given in this way, is known to ablate antibody production completely but temporarily. It is therefore concluded that even though infected mice make extremely poor antibody responses to heterologous antigens, they are still capable of producing sufficient antibody to control peaks of parasitaemia associated with the emergence of new variant antigenic types. The significance of these findings is disc...Continue Reading

References

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Citations

Feb 10, 1977·Nature·A N Jayawardena, B H Waksman
Dec 1, 1976·Experimental Parasitology·W J Herbert, W H Lumsden

Related Concepts

Mice, Inbred BALB C
Antibody Formation
IgM2
Antigens
Therapeutic Immunosuppression
Trypanosoma brucei brucei
Polyglobin
Hemolytic Plaque Technique
Nagana
Communicable Diseases

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