Immunodominance hierarchy of influenza subtype-specific neutralizing antibody response as a hurdle to effectiveness of polyvalent vaccine

Human Vaccines & Immunotherapeutics
Hoyoung LeeSooseong You

Abstract

Strengthening of immunodominance hierarchy of influenza subtype-specific neutralizing antibody response by annual polyvalent vaccinations could increase the variation of vaccine effectiveness by subtype. Therefore, we suggest the assessment of neutralizing antibody titer prior to seasonal vaccination and recommend the inoculation of only strains lower than protective levels.

References

Jan 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·Nicole L La GrutaPeter C Doherty
Jan 27, 2016·Human Vaccines & Immunotherapeutics·Janina E Linnik, Adrian Egli
Feb 14, 2017·Nature Immunology·Davide AngelettiJonathan W Yewdell

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