PMID: 7527073Aug 1, 1994Paper

Immunoelectron microscopic localization of E-cadherin in dorsal root ganglia, dorsal root and dorsal horn of postnatal mice

Journal of Neurocytology
N UchiyamaM Takeichi

Abstract

Sensory neurons and associated glial cells are known to express the cell-cell adhesion molecule E-cadherin. The cellular and subcellular localization of this molecule in the dorsal root ganglion, dorsal root, and spinal cord of postnatal mice was studied by the pre-embedding immunoelectron microscopic labelling technique. In the dorsal root and the superficial layer of the dorsal horn, a subset of fasciculating unmyelinated axons expressed E-cadherin at their axon-axon contacts at all ages studied, and these axons were clustered together and segregated from E-cadherin-negative axons. In contrast, pre-myelinating large-diameter axons in P2 mice as well as myelinated axons in mice from P14 to adulthood were E-cadherin-negative. Glial cells also expressed E-cadherin: In the dorsal root ganglia, all of the satellite cells expressed E-cadherin at contact sites with neurons, other satellite cells, and basal lamina, at all ages studied. In dorsal roots from P14 to adulthood, myelin-forming Schwann cells expressed E-cadherin at the outer mesaxons and the contact sites with basal lamina. Non-myelin-forming Schwann cells occasionally stained for this molecule at contact sites with the plasma membrane of E-cadherin-positive axons and at o...Continue Reading

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Citations

Apr 7, 2000·Journal of Neuroscience Methods·E M HirstG Raisman
Apr 25, 2000·Progress in Neurobiology·C Redies
Feb 1, 1996·Current Opinion in Neurobiology·R Mirsky, K R Jessen
Oct 13, 2001·Journal of Cellular Physiology·P PlaL Larue
Aug 17, 2001·Annals of Plastic Surgery·H TadaS Yurugi
Nov 1, 1996·Journal of Neurocytology·Y ShibuyaC Ide
Apr 14, 2020·Developmental Neurobiology·Emma R WilsonM Laura Feltri
Jun 1, 1996·Neuroscience Research·C Ide

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