Immunoepidemiology of meningococcal disease in military recruits. I. A model for serogroup independency of epidemic potential as determined by serotyping

The Journal of Infectious Diseases
J M GriffissM S Artenstein

Abstract

One hundred twenty strains of Neisseria meningitidis were serotyped with use of cross-absorbed rabbit antisera in a bactericidal test. Fifty-eight epidemic strains of serogroup B, C, and Y that occurred simultaneously among military recruits at two basic training centers during a period of epidemic meningococcal disease were compared with 62 strains of serogroups A, B, C, and Y isolated worldwide. Antisera to the six original antigenic factors of the Gold serotyping schema were adequate for typing 94% of strains, including all of the epidemic strains. The array of serotyping factors in the epidemic strains differed from those in the nonepidemic strains. Epidemic strains were almost exclusively of two serotypes, with type CII predominant among strains of groups B and C. Concurrent strains of groups B and C were invariably of the same serotype. A model for the epidemic potential of meningococcal strains, which is based on their serotype and serogroup antigens, and a modification of the original Gold typing schema are presented.

Citations

Jan 1, 1991·Transactions of the Royal Society of Tropical Medicine and Hygiene·J M GriffissJ J Kim
Nov 1, 1987·Archives of Disease in Childhood·K J CannC Burns
May 1, 1979·The Journal of Clinical Investigation·W D ZollingerS Berman
Jan 1, 1981·Critical Reviews in Microbiology·J E Sippel
Jun 1, 1982·Microbiological Reviews·I W DeVoe
Aug 1, 1984·Journal of Clinical Microbiology·S de MarieH C Zanen

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