Immunoexpression of Cbfa-1/Runx2 and VEGF in sinus lift procedures using bone substitutes in rabbits

Clinical Oral Implants Research
Leandro Soeiro De Souza NunesMariza Akemi Matsumoto

Abstract

To analyze and compare the expression of core binding factor-1 (Cbfa-1)/Runx2 and vascular endothelium growth factor (VEGF) in sinus lift procedures using bovine hydroxyapatite (HA) and beta-tricalcium phosphate (beta-TCP). Twenty-four male rabbits that had undergone bilateral sinus lift procedures were divided into three groups, according to the sinus filling material: Group 1: autogenous bone graft; Group 2: bovine HA; and Group 3: beta-TCP. All groups were sacrificed after 7, 14, 30 and 60 days, for microscopic, histomorphometry and immunohistochemistry analysis. Microscopic analysis showed a similar bone repair pattern between the tested groups. New bone formation, soft and medular tissue, remaining material or particulate bone graft area were obtained by histomorphometric analysis. After 14 days, statistically significant differences in new bone formation were found between Group 1 (27.76+/-7.8) and Groups 2 (14.22+/-3.2) and 3 (11.1+/-7.7). After 30 days, statistically significant differences (P<0.05) were detected in bone formation between Groups 1 (31.39+/-36.5) and 2 (14.13+/-3.2). The last period showed improved bone formation in Group 2. Also, Group 2 showed higher Cbfa-1/Runx2 immunoexpression when compared with Gro...Continue Reading

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Citations

Mar 20, 2012·Journal of Materials Science. Materials in Medicine·Mariza Akemi MatsumotoRoberto Yoshio Kawakami
Apr 27, 2013·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Stefan Stübinger, Michel Dard
Dec 30, 2015·Journal of Materials Science. Materials in Medicine·Rodrigo Ricci VivanMariza Akemi Matsumoto
Feb 27, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Helder ValienseMônica D Calasans-Maia
May 12, 2012·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Tomasz GredesChristiane Kunert-Keil
Aug 1, 2015·Journal of Maxillofacial and Oral Surgery·Marcelo Rodrigues AzenhaOsvaldo Magro Filho
Dec 16, 2016·The Journal of Craniofacial Surgery·Seda YilmazBerrin Zuhal Altunkaynak
Apr 5, 2016·Tissue Engineering and Regenerative Medicine·Sook Kyoung KimSoon Jung Hwang

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