Immunoexpression of galectin-3 in colorectal cancer and its relationship with survival.

Journal of Gastrointestinal Cancer
Luciana Zaia PoveglianoNora Manoukian Forones

Abstract

Galectin-3 is an endogenous galactose-binding protein that is expressed in a wide range of normal and neoplasic tissues and is thought to be involved in cellular adhesion, growth regulation, and apoptosis. Galectin-3 seems to have an important role in colorectal cancer. The aim of this study was to evaluate the immunoexpression of galectin-3 in patients with colorectal cancer under surgery and chemotherapy treatment and the relationship of galectin-3 expression and clinical aspects or tumor evolution. Galectin-3 expression was examined immunohistochemically in 75 samples of colorectal tissues. A scoring system was used to evaluate the cytoplasmic cells color. Among the patients, 40 were female; the average age was 61.98 years old. According to the site, 42.6% was of the rectum, 33.4% right colon, and 24% left colon. Thirty-three tumors were stage II, 32 stage III, and ten stage IV. Galectin-3 immunoexpression was classified as 1 in 57.33% of tumors. The highest percentage of staining cells appeared in the most advanced cancer (p = 0.4899). Patients with recurrence had a great number of tumors with high score (p = 0.0465). In addition, high or moderate galectin-3 immunoexpression had been associated with an increased marginal ri...Continue Reading

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Sep 13, 2011·Pathology Oncology Research : POR·Matthias M GaidaMoritz N Wente
Feb 6, 2014·Journal of Endocrinological Investigation·H YilmazR Yigitoglu
Mar 20, 2012·Trends in Molecular Medicine·Shigeru TsuboiMinoru Fukuda
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Mar 12, 2020·Einstein·Mariana Pacífico GarvilSanívia Aparecida de Lima Pereira
Sep 3, 2019·Pathology, Research and Practice·Chengyan WangLijuan Pang

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