Immunoexpression of LGR4 and Β-Catenin in Gastric Cancer and Normal Gastric Mucosa

Asian Pacific Journal of Cancer Prevention : APJCP
Susana Moreira de SouzaPaulo Roberto Carvalho de Almeida

Abstract

Background: We evaluated the immunoexpression of LGR4 and β-catenin in primary gastric carcinomas, lymph node metastases and histologically normal gastric mucosa in the surgical margins of gastric primary tumours. Methods: We performed a cross-sectional, observational study, based on 75 gastric carcinoma specimens from gastrectomies conducted at the hospital of the Federal University of Ceará, Brazil. The samples were analysed by tissue microarray and immunohistochemistry. Chi-square, Fisher’s exact test and Pearson’s linear regression were used in this study. Results: LGR4 expression was greater in the histologically normal gastric mucosa (basal third of the epithelial thickness) of the tumour surgical resection margin than in the cases of primary carcinomas (P<0.001, mainly diffuse-histotype cancer margins), and also in the number of cells stained in the normal mucosa (P<0.0001). Primary intestinal-type carcinomas showed greater positivity for LGR4 than diffuse tumours (59% vs 13%, P<0.0001) and in these the positivity was higher in the metastases (P=0.0242). The membranous immunoexpression of β-catenin was ubiquitous in the normal mucosa and present in 2/3 of the positive carcinomas. In only one case, nuclear β-catenin expre...Continue Reading

Citations

Mar 17, 2020·Cancer Biomarkers : Section a of Disease Markers·Zhaoyang ZengXin Feng
May 29, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Fernanda Costa Brandão BertiDanielle Malheiros

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BETA
surgical resection

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GraphPad Prism

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