PMID: 11337204May 5, 2001Paper

Immunofluorescence and immunoelectron microscopic evidence for differences in myelination of GABAergic and cholinergic septohippocampal fibres

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
U GärtnerT Arendt

Abstract

It is known that the rat septohippocampal projection is realised at least by GABAergic, parvalbumin containing and cholinergic fibres. The GABAergic component originates from fast-firing and fast-conducting neurons, whereas the cholinergic component represents the slow-firing, slow-conducting type. The present immunofluorescence and immunoelectron microscopic study shows that the vast majority of parvalbumin-immunoreactive, GABAergic axons are surrounded by enormously thick myelin sheaths, but choline acetyltransferase immunoreactive axons were rarely found to be myelinated. In addition, cholinergic fibres show considerably smaller diameters. Accordingly, our results are correlated with the well-known differences in conduction velocities between the GABAergic and cholinergic fibres of the septohippocampal pathway, which depend on myelination and axon calibre.

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Citations

May 5, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R Schliebs
Oct 22, 2014·Translational Psychiatry·K G SchrautD L Van den Hove
Jan 19, 2016·Pharmacology, Biochemistry, and Behavior·Fatemeh KhakpaiMohammad-Reza Zarrindast
Dec 14, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Hajnalka ÁbrahámLászló Seress
Apr 27, 2010·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Hajnalka AbrahámLászló Seress
Jul 29, 2018·The European Journal of Neuroscience·Nicola Solari, Balázs Hangya
Aug 5, 2020·Nature Reviews. Neuroscience·Sarah Melzer, Hannah Monyer

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