PMID: 7004527Nov 1, 1980

Immunofluorescence study of lactoferrin-synthesizing thymus cells

Biulleten' eksperimental'noĭ biologii i meditsiny
E V GnezditskaiaK L Shakhanina

Abstract

Lactoferrin-synthesizing cells were detected in the human thymus by immunofluorescence. LF cells in the thymus were shown to be more numerous, to possess greater secretory activity, and to appear earlier in the process of embryonal development as compared to the organ producing this protein (salivary gland). The data obtained suggest that in the thymus, lactoferrin apart from its known functions, bacteriostatic and ferrous iron-binding ones, acts as a heteroorgan antigen, i.e. provides lymphocytes of the thymus with information on this protein structure during natural immunologic tolerance induction.

References

Feb 1, 1976·Biulleten' eksperimental'noĭ biologii i meditsiny·L V BeletskaiaI I Rassokhina
Jan 1, 1976·American Journal of Surgery·H H LeVeenM Patel
Sep 1, 1969·The Journal of Experimental Medicine·P L MassonE Schonne
Mar 1, 1970·The Journal of Experimental Medicine·M BaggioliniJ F Heremans
Mar 1, 1964·Proceedings of the Society for Experimental Biology and Medicine·H VAN DER GELDH J OOSTERHUIS

Related Concepts

Immunofluorescence Assay
Natural Immunosuppression
Lactoferrin
Lactoglobulins
Liver
Tissue Specificity
Salivary Glands
Thymus Gland
Drug or Chemical Tissue Distribution
Palatine Tonsil

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