PMID: 6403452Apr 1, 1983Paper

Immunofluorescence study of "non-idiopathic" renal amyloidosis

Human Pathology
C OrfilaJ M Suc

Abstract

The authors report the results of immunofluorescence (IF) studies of 17 cases of "non-idiopathic" renal biopsy-proven amyloidosis and 18 cases of various nephropathies and normal kidneys (as controls), investigated by IF by simultaneous use of antisera against routine IgG, IgM, IgA, C3, C4, Clq, beta-lipoprotein, albumin, and fibrinogen. Antisera against kappa and lambda light chains and amyloid A and amyloid P components were also used. Six of the 17 cases of amyloidosis were associated with immunocyte dyscrasia, and 11 were cases of reactive systemic amyloidosis associated with chronic infections or inflammatory and neoplastic disorders. In amyloidosis, IF deposits appeared for all antisera as homogeneous staining of mesangial nodules, and, more rarely, there was staining along the glomerular basement membranes. Overall immunoglobulins and C3 were present in 11 cases (64 per cent). Kappa and lambda light chains were demonstrated in 14 (82 per cent) and 12 (70 per cent) cases, respectively. In immunocyte dyscrasia associated with amyloidosis, immunoglobulin and light-chain deposits corresponding to a paraprotein abnormality were demonstrated in glomeruli and in tubular casts. Amyloid P component was always present in glomeruli...Continue Reading

Citations

Jan 1, 1986·Virchows Archiv. A, Pathological Anatomy and Histopathology·C A van de KaaE Gruys
Nov 1, 1987·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section A, Pathology·H LöfbergA Grubb
Sep 1, 1987·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section A, Pathology·H LöfbergN H Sternby
Sep 4, 2001·International Journal of Hematology·J GardynA M Cohen
Dec 28, 1999·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·M NyboS E Svehag
Mar 1, 1987·Kidney International·C E AlpersC G Biava

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