PMID: 7008824Mar 1, 1981Paper

Immunofluorescent studies of the uteroplacental arteries in normal pregnancy

British Journal of Obstetrics and Gynaecology
P E Weir

Abstract

Immunofluorescent studies were performed on placental bed biopsies from 27 normal pregnancies. Uteroplacental arteries were present in 26 of the 27 biopsies and all showed deposition of fibrin in relation to the fibrinoid layer within the vessel wall; 12 also showed deposition of C3. Interstitial fibrinoid deposits also stained positively with fibrin. There was no deposition of immunoglobulins within the arterial changes nor in association with intramural or interstitial trophoblast. This study indicates that fibrin is a significant contributor to the fibrinoid layer within the uteroplacental arteries, and suggests that the presence of bound C3 is due to the activation of the complement system by fibrinogenesis. There was no evidence that the humoral immune response was involved in the aetiology of the physiological changes in the uteroplacental arteries.

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Citations

Oct 1, 1987·Journal of Reproductive Immunology·M WellsC S Holgate
Jan 24, 2002·The Journal of Experimental Medicine·V Michael HolersJane E Salmon
Sep 4, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Yeon Mee KimSteven J Korzeniewski
Feb 3, 2016·Scientific Reports·Natalia E PovedaJorge E Caminos
Aug 1, 1986·American Journal of Obstetrics and Gynecology·W B RobertsonJ Bonnar
May 24, 2011·Molecular Immunology·Guillermina GirardiSicco Scherjon
Apr 10, 2007·Journal of Reproductive Immunology·Jane E Salmon, Guillermina Girardi
Jan 16, 2009·American Journal of Reproductive Immunology : AJRI·Emiliana KonovaYehuda Shoenfeld
Aug 29, 2012·American Journal of Reproductive Immunology : AJRI·Kerina J DennyLeonie K Callaway
Sep 1, 1992·Baillière's Clinical Obstetrics and Gynaecology·J N Bulmer
Jul 19, 2005·Molecular Immunology·Guillermina GirardiFrancesco Tedesco
Jun 17, 2015·Placenta·J H W VeerbeekA Franx
Jan 12, 2017·Biological Research for Nursing·Alexis B DunnElizabeth J Corwin
Apr 1, 1985·American Journal of Reproductive Immunology and Microbiology : AJRIM·C LabarrereO Althabe
Nov 1, 1988·Histopathology·M Wells, J N Bulmer

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