PMID: 2117929Jul 1, 1990Paper

Immunofractionation of high density lipoprotein subclasses 2 and 3. Similarities and differences of fractions isolated from male and female populations

Atherosclerosis
R W James, D Pometta

Abstract

High density lipoprotein (HDL) subclasses 2 and 3 isolated from male and female populations were further subfractionated by immunoaffinity techniques. Each subclass gave rise to 2 fractions: one contained apolipoprotein (apo) A-I but no apo A-II (LpAI); the other contained apo A-I and apo A-II (LpAI,AII). The bulk fraction (HDL-3(LpAI,AII)) comprised over 70% of total HDL and was present in similar concentrations in both populations. There were, however, significant male-female differences in plasma levels of the minor HDL-3 fraction i.e. HDL-3(LpAI). Females had significantly higher plasma concentrations of both fractions within HDL-2. These fractions also exhibited strong, positive correlations with total HDL cholesterol concentrations, both in males as well as females. It suggests that metabolic activities giving rise to both HDL-2(LpAI) and HDL-2(LpAI,AII) determine plasma HDL cholesterol concentrations. Several similarities were noted between the male and female populations. Triglyceridaemia was negatively correlated with HDL-2 derived fractions and positively correlated with the bulk fraction HDL-3(LpAI,AII). Compositional data showed that the fraction (LpAI) had a lower esterified cholesterol to total cholesterol ratio t...Continue Reading

References

Nov 1, 1987·Atherosclerosis·P PuchoisJ C Fruchart
Jul 1, 1987·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·D RobinsonD J Galton
Oct 1, 1966·Circulation·J W GofmanR Tandy
Sep 1, 1983·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J F Oram
May 1, 1984·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·R J DeckelbaumS Eisenberg
Jun 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P E Fielding, C J Fielding
May 1, 1982·Metabolism: Clinical and Experimental·F C BallantyneD Ballantyne
Sep 24, 1981·Biochimica Et Biophysica Acta·P J BlancheA V Nichols
Feb 14, 1980·Clinica Chimica Acta; International Journal of Clinical Chemistry·J ShepherdH G Morgan

❮ Previous
Next ❯

Citations

Oct 10, 2009·Diabetologia·N TolonenUNKNOWN FinnDiane Study Group
Oct 30, 1992·Clinica Chimica Acta; International Journal of Clinical Chemistry·I FreyJ Keul
Oct 1, 1994·Atherosclerosis·J R Patsch
Feb 10, 2009·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·F R JornayvazR W James
Sep 2, 2008·Journal of Lipid Research·Natasa BulatChristian Widmann

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.