PMID: 6972765Jun 1, 1981Paper

Immunogenetic control of experimental type II collagen-induced arthritis. I. Susceptibility and resistance among inbred strains of rats

Arthritis and Rheumatism
M M GriffithsC W DeWitt

Abstract

Seven inbred rat strains were tested for susceptibility to experimental type II collagen-induced arthritis and for development of cellular immunity to type II collagen by delayed hypersensitivity skin testing. WF (RT1u), LEW (RT1l), and DA (RT1a) were the most susceptible of the strains tested with respect to incidence (greater than 95%) and severity of disease. LEW and DA were strongly skin test reactive to calf type II collagen. BUF (RT1b) developed moderate skin test responses to calf type II collagen and showed low susceptibility to collagen arthritis (1/8). MAXX (RT1n), LEW.B3 (RT1nvl), and AUG (RT1c) were not susceptible to collagen arthritis and showed negative to very weak skin test responses to type II collagen. Disease susceptibility was inherited as a dominant trait in the F1 progeny of (WF X LEW.B3) matings. These data suggest that clinical expression of experimental collagen-induced arthritis and immune responsiveness to type II collagen are controlled in part by genes within or closely linked to the rat major histocompatibility complex--RT1.

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Citations

Oct 1, 1996·Arthritis and Rheumatism·G W CannonM M Griffiths
Dec 4, 1998·Springer Seminars in Immunopathology·A P Cope, G Sønderstrup
Jul 1, 1993·Agents and Actions·K InoueK Kimura
Dec 16, 1991·Clinica Chimica Acta; International Journal of Clinical Chemistry·B Pérez-MacedaC Bernabeu
Feb 1, 1986·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·R S PereiraJ D Spencer
Jul 16, 2011·Journal of Medicinal Chemistry·Ameya GokhaleSeetharama D Satyanarayanajois
Dec 22, 1999·Clinical and Experimental Immunology·R M GoodfellowB P Morgan
Dec 1, 1983·The Journal of Experimental Medicine·N KaibaraI Katsuki
May 1, 1984·The Journal of Experimental Medicine·N KaibaraS Jingushi
Nov 1, 1994·The Journal of Experimental Medicine·K BankiA Perl
Jan 13, 2000·Immunological Reviews·G SønderstrupH O McDevitt
Dec 1, 1983·Annals of the Rheumatic Diseases·K MorganP J Lennox Holt
Aug 1, 1995·The Journal of Clinical Investigation·D B KnoerzerL J Mengle-Gaw
Dec 18, 2003·The Journal of Clinical Investigation·Veena TanejaChella S David

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