PMID: 6983354Dec 1, 1982Paper

Immunogenetic factors in inflammatory eye disease. Influence of HLA-B27 and alpha 1-antitrypsin phenotypes on disease expression

Arthritis and Rheumatism
D WakefieldR Penny

Abstract

The relationship between the nature and severity of inflammatory eye disease was analyzed with respect to HLA antigens and alpha 1-antitrypsin phenotypes. Using standard ophthalmologic criteria, we divided patients with anterior uveitis into acute, chronic (greater than 3-month duration), bilateral, or recurrent disease. There was a significantly increased incidence of alpha 1-antitrypsin-deficient phenotypes in anterior uveitis, especially in those patients with severe (chronic, bilateral, or recurrent) disease. HLA-B27 acts as an independent predisposing factor: it was present in 22% of patients with their first attack of acute uveitis compared with 51% of patients with recurrent disease. Together, these genetic factors are present in 63% of patients with severe anterior uveitis and represent the most significant predisposing and prognostic factors so far detected.

Citations

Apr 1, 1988·Human Immunology·D WakefieldB Pussell
May 1, 1990·Australian and New Zealand Journal of Ophthalmology·D Wakefield, P McCluskey
Dec 8, 1998·Australian and New Zealand Journal of Ophthalmology·J R Smith, D J Coster
Jul 1, 1985·The British Journal of Ophthalmology·D WakefieldR Penny
Aug 1, 1988·The British Journal of Ophthalmology·I R FearnleyF Muncey
Jun 1, 1985·Clinical Immunology and Immunopathology·S N BreitR Penny
Apr 12, 2005·Clinical Biochemistry·Saeid GhavamiEnrique Fernandez Bustillo
Aug 1, 1986·Australian and New Zealand Journal of Ophthalmology·D WakefieldR Penny
Nov 12, 2002·International Reviews of Immunology·Giuseppina Pennesi, Rachel R Caspi
Oct 1, 1986·Acta Ophthalmologica·K M SaariA W Eriksson
Nov 1, 1985·Arthritis and Rheumatism·G P Astorga, M T Cuchacovich
Apr 3, 2004·American Journal of Ophthalmology·Charlie W WuTimothy W Olsen

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