Immunogenetic factors in the selection of cord blood units for transplantation: current search strategies and future perspectives

Cytotherapy
Kirsten Geneugelijk, Eric Spierings

Abstract

Hematopoietic stem cell transplantation is currently used as a curative treatment for patients with malignant and non-malignant hematologic diseases. Human leukocyte antigen (HLA) matching is a major determinant for hematopoietic stem cell transplantation outcome. For patients lacking a fully HLA-matched donor, umbilical cord blood (UCB) units are alternative sources of hematopoietic stem cells because UCB transplantation allows a less stringent HLA matching. However, selection of the optimal UCB units remains challenging. The current UCB donor selection strategies are based on both cell dose and HLA matching. This Review focuses on the immunogenetic factors that influence UCB donor selection and highlights the future perspectives in UCB donor search.

References

Jan 26, 1989·The New England Journal of Medicine·C AnasettiE Mickelson
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·E S SongR S Goodenow
Jul 18, 1996·The New England Journal of Medicine·J KurtzbergP Rubinstein
Nov 26, 1998·The New England Journal of Medicine·P RubinsteinC E Stevens
Sep 10, 2002·Transplant Immunology·David S Game, Robert I Lechler
Mar 31, 2004·Experimental Hematology·Eliane GluckmanUNKNOWN Eurocord Group
Nov 27, 2004·The New England Journal of Medicine·Mary J LaughlinMary M Horowitz
May 15, 2007·Tissue Antigens·B AfzaliM P Hernandez-Fuentes
Mar 28, 2008·Transfusion·Minoko TakanashiKazunori Nakajima
Aug 14, 2008·Transplantation·Paul I Terasaki, Junchao Cai
Jan 20, 2009·Leukemia·R WillemzeUNKNOWN Eurocord-Netcord and Acute Leukaemia Working Party of the EBMT
Oct 3, 2009·British Journal of Haematology·Angela R Smith, John E Wagner
Nov 11, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jon J van RoodAndromachi Scaradavou
Jun 19, 2010·The Lancet Oncology·Mary EapenUNKNOWN National Cord Blood Program of the New York Blood Center
Jul 16, 2010·Blood·Minoko TakanashiShunichi Kato
Aug 31, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Juliet N BarkerMarcel R M van den Brink
Sep 15, 2010·Best Practice & Research. Clinical Haematology·Roel WillemzeUNKNOWN Eurocord and of the European Group of Blood and Marrow Transplantation
Feb 1, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Kristin M PageJoanne Kurtzberg
May 24, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Claudio G BrunsteinJohn E Wagner

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.