PMID: 6406375Feb 1, 1983Paper

Immunogenetic markers and immune response in patients with recurrent oral ulceration

International Journal of Oral Surgery
M MalmströmF Fyhrquist

Abstract

20 patients, aged 20 to 72 years (mean 36.5 years), 14 with recurrent (RAS) and 6 with recurrent cicatrizing (RCAS) aphthous stomatitis were studied. 3 patients (15%) had the HLA locus A11 antigen, whose frequency in the Finnish population is 8%. 5 patients (25%) had B12, which occurs in 15% of the normal population. Results of routine serological tests were normal. All had normal serum levels of IgG, IgM, IgA and complements C3 and C4. 4 patients, 2 with RAS and 2 with RCAS, had raised serum IgE. Precipitating antibodies against milk protein were detected in 2 patients and against gluten in 1. In 4 patients, tests for immediate allergy were positive. 5 patients had antibodies to double-stranded DNA. Delayed hypersensitivity reactions were normal, and the PHA stimulation of lymphocytes elicited normal T-cell responses in all patients except one with RCAS. In this patient, there was a striking parallelism between an increase in PHA-reactive lymphocytes and clinical improvement. The serum of this patient contained a binder for 125I-labelled PHA, a binder not consistently detected in the other patients with ROU. Lymphocyte dysfunction may play a rôle in ROU. Of the 16 biopsy specimens of aphthous tissue studied by direct immunoflu...Continue Reading

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Citations

Jul 1, 1991·Clinical and Experimental Dermatology·S R Porter, C Scully
Nov 13, 2013·Archivum Immunologiae Et Therapiae Experimentalis·Zuzanna SlebiodaAnna Kowalska
Oct 20, 2007·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Michael John McCulloughCrispian Scully
Feb 1, 1987·Journal of Oral Pathology·J BaggD M Walker
Jan 1, 1992·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·S R PorterJ Bowden
May 1, 1992·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·R Häyrinen-ImmonenY T Konttinen
Jan 1, 1989·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·C Scully, S Porter
Jan 1, 1989·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·A PedersenJ P Stenvang
Nov 1, 1996·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·M VicenteA Ramos
Aug 1, 1992·Scandinavian Journal of Dental Research·R Häyrinen-Immonen
Dec 1, 1991·Scandinavian Journal of Dental Research·R Häyrinen-ImmonenY T Konttinen
Sep 26, 2003·American Journal of Clinical Dermatology·A Ross Kerr, Jonathan A Ship
Jan 5, 2006·Oral Diseases·S JurgeS R Porter

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