PMID: 9442800Jan 27, 1998Paper

Immunogenetics of Henoch-Schoenlein disease

European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics
A AmorosoF Scolari

Abstract

In order to investigate the genetic basis of susceptibility to Henoch-Schoenlein purpura (HS), blood samples of 152 patients, 105 of whom had renal disease, were collected in a two-step study. The evaluation of DRB, DQB and DQA polymorphism was done by analysis of the restriction polymorphisms produced by TaqI enzyme. DRB1*07 was less frequent in patients than in the control group (gene frequency 0.09 and 0.18, respectively; P = 0.0023), whereas 64% of the patients were positive for DRB1*01 and/or DRB1*11 compared with 48% of the control group (P = 0.0069). Polymerase chain reaction-sequence-specific oligonucleotide (PCR-SSO) typing of DRB1*01- and DRB1*11-positive individuals did not show any deviation of frequencies of DRB1*01 subtypes between patients and controls, whereas among DRB1*11 subtypes DRB1*1104 was significantly increased in the patients (Pc = 0.033). The comparison between patients with renal disease and those without renal disease showed no significant differences in the frequency of the single DRB, DQB and DQA alleles. The study of restriction polymorphisms in the switch region of the constant genes alpha 1, alpha 2 and mu of the heavy chains of immunoglobulins, using the enzyme Sacl and a specific probe, did n...Continue Reading

Citations

Jan 18, 2013·Rheumatology International·Xuelian HeWei Yin
May 2, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Oguz SoylemezogluEnver Hasanoglu
May 10, 2007·Clinical Rheumatology·Harun PeruEnver Hasanoglu
Jan 7, 2010·Current Opinion in Rheumatology·Paul A Monach, Peter A Merkel
May 18, 2010·Current Opinion in Rheumatology·Frank T Saulsbury
Jan 16, 2013·Current Opinion in Rheumatology·Maryam Piram, Alfred Mahr
Jul 5, 2001·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·G Rostoker
May 18, 2016·Human Immunology·Ritu AggarwalSurjit Singh
Dec 4, 2014·Arthritis & Rheumatology·Raquel López-MejíasMiguel A González-Gay
Jan 13, 2010·International Journal of Dermatology·Lenis M GonzálezRobert A Schwartz
Sep 13, 2018·Nature Reviews. Nephrology·Kate J RobsonA Richard Kitching
Aug 30, 2005·Scandinavian Journal of Infectious Diseases·Nikolaos SpyridisPanayiotis Spyridis
Nov 22, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Licia Peruzzi, Rosanna Coppo
Feb 17, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mikael KoskelaTimo Jahnukainen
Dec 10, 1999·Journal of the American Society of Nephrology : JASN·A RaiS Adler
Nov 29, 2001·Rheumatic Diseases Clinics of North America·M A González-Gay, C García-Porrúa

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