Immunogenetics of two new HLA alleles: A*0108 and B*4031

Tissue Antigens
J StreetC Darke

Abstract

Two new alleles, HLA-A*0108 and B*4031, were identified in north-western European Caucasoid subjects. A*0108 differed from A*010101 by a single substitution (C to T) at position 216 in exon 3, resulting in an amino acid difference of Arg to Trp at position 163. It was present on a haplotype with B*1501/60/70/71; Cw*0303; DRB1*1301; DRB3*0202; DQA1*0103; DQB1*0603 and its product reacted as a normal HLA-A1 specificity. B*4031 differed from B*4001 by two nucleotides in exon 3 (positions 20 (G to C) and 69 (A to G)) resulting in two amino acid differences (Arg to Ser at position 97 and Asn to Asp at position 114). It was found on a haplotype with HLA-A*03; Cw*0304; DRB1*0404/32; DRB4*0101/3/5; DQA1*03; DQB1*0302 and has the HLA-B60 specificity. Both alleles have frequencies of < 0.0002 in the largely north-western European Caucasoid blood donor population resident in Wales.

References

Nov 1, 1983·Tissue Antigens·C Darke
Jan 1, 1997·Human Immunology·R F SchipperM Oudshoorn
May 14, 1999·Tissue Antigens·M G GuttridgeC Darke
Jul 8, 1999·Experimental and Clinical Immunogenetics·C DarkeS McNamara
Jul 8, 1999·Tissue Antigens·C DarkeM Thomas
Jan 6, 2001·Tissue Antigens·S G Marsh, UNKNOWN WHO Nomenclature Committee for Factors of the HLA System
Apr 4, 2001·Tissue Antigens·S G MarshP I Terasaki

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Citations

Jun 7, 2005·Human Immunology·Wendy T N SwelsenElla M van den Berg-Loonen
Apr 17, 2004·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·H BassC Darke

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