Immunogenic and protective properties of haemagglutinin protein (H) of rinderpest virus expressed by a recombinant baculovirus

Vaccine
S NaikM S Shaila

Abstract

The hemagglutinin (H) protein of Rinderpest virus expressed by a recombinant baculovirus used as a vaccine produced high titres of neutralizing antibody to Rinderpest virus in the vaccinated cattle, comparable to the levels produced by live attenuated vaccine. The immunized cattle were protected against a vaccine-virus challenge, as demonstrated by the failure of development of antibodies to N protein of the vaccine virus. The lack of replication of vaccine virus in the immunized cattle indicated that they are capable of showing a protective response if challenged with a virulent virus.

References

Sep 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·L GiavedoniT Yilma
Jan 1, 1989·Archives of Virology·K TsukiyamaK Yamanouchi
Jan 1, 1980·Reviews of Infectious Diseases·P W Choppin, A Scheid

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Citations

Mar 29, 2001·Viral Immunology·G SinnathambyM S Shaila
Jul 20, 2002·Virology·G J RenukaradhyaM S Shaila
Aug 11, 2019·Viruses·Meera PrajapatiZhidong Zhang

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