Immunogenic dendritic cells primed by social defeat enhance adaptive immunity to influenza A virus.

Brain, Behavior, and Immunity
Nicole D PowellJohn F Sheridan

Abstract

Dendritic cells (DCs) sample their surrounding microenvironment and consequently send immunogenic or regulatory signals to T cells during DC/T cell interactions, shaping the primary adaptive immune response to infection. The microenvironment resulting from repeated social defeat increases DC co-stimulatory molecule expression and primes DCs for enhanced cytokine responses in vitro. In this study, we show that social disruption stress (SDR) results in the generation of immunogenic DCs, capable of conferring enhanced adaptive immunity to influenza A/PR/8/34 infection. Mice infected with influenza A/PR/8/34 virus 24 h after the adoptive transfer of DCs from SDR mice had significantly increased numbers of D(b)NP(366-74)CD8(+) T cells, increased IFN-γ and IFN-α mRNA, and decreased influenza M1 mRNA expression in the lung during the peak primary response (9 days post-infection), compared to mice that received DCs from naïve mice. These data demonstrate that repeated social defeat is a significant environmental influence on immunogenic DC activation and function.

Citations

Feb 1, 2012·Molecular Psychiatry·C L Raison, A H Miller
Aug 6, 2011·Nature Reviews. Immunology·Michael R Irwin, Steven W Cole
Sep 26, 2013·Proceedings of the National Academy of Sciences of the United States of America·Nicole D PowellSteven W Cole
Sep 2, 2011·BMC Infectious Diseases·Raquel AlmansaJesus F Bermejo-Martin
Jul 6, 2014·PloS One·Nani MorganChenchen Wang
Jan 23, 2016·Brain, Behavior, and Immunity·Mark P YeagerPaul M Guyre
Jul 14, 2012·Brain, Behavior, and Immunity·N D PowellJ F Sheridan
Dec 17, 2014·Translational Psychiatry·E Beurel, R S Jope
Sep 16, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Charles L Raison, Andrew H Miller
Jul 31, 2018·Frontiers in Behavioral Neuroscience·Oliver AmbréeJudith Alferink
Aug 29, 2017·Annual Review of Psychology·Eric PakulakHelen Neville
Mar 10, 2016·Biological Research for Nursing·Kord M KoberBradley E Aouizerat
Jun 10, 2021·Brain, Behavior, and Immunity·Emily AllgireRenu Sah

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