Immunogenic Effect of Hyperthermia on Enhancing Radiotherapeutic Efficacy

International Journal of Molecular Sciences
Sungmin LeeBuHyun Youn

Abstract

Hyperthermia is a cancer treatment where tumor tissue is heated to around 40 °C. Hyperthermia shows both cancer cell cytotoxicity and immune response stimulation via immune cell activation. Immunogenic responses encompass the innate and adaptive immune systems, involving the activation of macrophages, natural killer cells, dendritic cells, and T cells. Moreover, hyperthermia is commonly used in combination with different treatment modalities, such as radiotherapy and chemotherapy, for better clinical outcomes. In this review, we will focus on hyperthermia-induced immunogenic effects and molecular events to improve radiotherapy efficacy. The beneficial potential of integrating radiotherapy with hyperthermia is also discussed.

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Citations

Sep 22, 2019·Cells·Wanyeon KimBuHyun Youn
Oct 28, 2019·Oncoimmunology·Jenny SprootenAbhishek D Garg
Jul 17, 2020·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Georgios P SkandalakisConstantinos G Hadjipanayis
Oct 28, 2019·Scientific Reports·Maria HarmatiKrisztina Buzas
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May 1, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Macy PayneMatthew T Basel
Sep 10, 2019·International Journal of Radiation Biology·Beomseok SonBuHyun Youn
Dec 29, 2019·Seminars in Cancer Biology·Maria L GuevaraStefano Persano

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