Immunogenicity and efficacy of alphavirus-derived replicon vaccines for respiratory syncytial virus and human metapneumovirus in nonhuman primates

Vaccine
John T BatesJames E Crowe

Abstract

Human respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) are major causes of illness among children, the elderly, and the immunocompromised. No vaccine has been licensed for protection against either of these viruses. We tested the ability of two Venezuelan equine encephalitis virus-based viral replicon particle (VEE-VRP) vaccines that express the hRSV or hMPV fusion (F) protein to confer protection against hRSV or hMPV in African green monkeys. Animals immunized with VEE-VRP vaccines developed RSV or MPV F-specific antibodies and serum neutralizing activity. Compared to control animals, immunized animals were better able to control viral load in the respiratory mucosa following challenge and had lower levels of viral genome in nasopharyngeal and bronchoalveolar lavage fluids. The high level of immunogenicity and protective efficacy induced by these vaccine candidates in nonhuman primates suggest that they hold promise for further development.

References

Apr 1, 1991·The Journal of Infectious Diseases·C B HallK C Schnabel
Feb 1, 1995·The Journal of Infectious Diseases·I R SamiG A Prince
Jan 30, 2004·The New England Journal of Medicine·John V WilliamsJames E Crowe
Aug 23, 2005·Proceedings of the American Thoracic Society·Peter L Collins, Brian R Murphy
Oct 20, 2006·Journal of Virology·Gabriella CsekeJohn V Williams
May 14, 2010·Clinical and Vaccine Immunology : CVI·Stanley A Plotkin
Sep 30, 2010·Clinical and Vaccine Immunology : CVI·Sukathida Ubol, Scott B Halstead
Jan 5, 2011·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Paul A ChecchiaRobert C Welliver
Jan 26, 2011·Virology Journal·Tanja I NäslundPeter Liljeström
Apr 8, 2011·Journal of Clinical Microbiology·Maja KodaniBarry S Fields
Jun 9, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Jennifer KlemencJohn V Williams
Feb 15, 2013·The New England Journal of Medicine·Kathryn M EdwardsUNKNOWN New Vaccine Surveillance Network
Jun 27, 2013·Nanotechnology·John W StoneJames E Crowe
Feb 7, 2014·Nature·Bruno E CorreiaWilliam R Schief
Feb 12, 2014·Influenza and Other Respiratory Viruses·Kyle WidmerH Keipp Talbot

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Citations

Jun 14, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Hirokazu KimuraAkihide Ryo
Nov 10, 2016·Vaccines·Kenneth Lundstrom
Dec 3, 2016·Vaccine·Geraldine Taylor
Jan 25, 2017·Expert Review of Vaccines·Verónica Araceli Márquez-Escobar
Feb 20, 2020·Pathogens·Charles J RussellJulia L Hurwitz
May 11, 2018·F1000Research·Nazly Shafagati, John Williams
Dec 13, 2018·Virusdisease·Prashant Kumar, Mansi Srivastava
Aug 28, 2020·Molecular Pharmaceutics·Satoshi UchidaHoracio Cabral
Apr 26, 2021·Molecular Immunology·Julien LemaitrePauline Maisonnasse
Jul 15, 2016·Clinical Microbiology Reviews·Pablo F CéspedesSusan M Bueno

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