Immunogenicity and lower dose requirement of polymer entrapped tetanus toxoid co-administered with alum

Vaccine
Yogesh K Katare, Amulya K Panda

Abstract

Low adjuvanticity of microparticles based vaccine formulation necessitates the use of alum along with particles to elicit improved antibody titers from single point immunization. It was observed that antibody response from immunization with admixture of alum and polymer entrapped antigen was dependent on particle size, amount of antigen released during burst phase and dose of microencapsulated antigen. In the animals immunized with polymer entrapped tetanus toxoid (TT) very large particles (50-150 microm) did not elicited high antibody titers where as microparticles in the range 2-8 microm exhibited remarkable improvement in the antibody response. Very small size particles (<2 microm) were also not as effective as 2-8 microm size particles for generation of antibody response. Presence of alum improved the immune response by adsorbing the burst released antigen from the particle surfaces. Role of alum in potentiation of immune response from polymer entrapped TT was highly significant at lower dose regimes. Polymer entrapped TT as little as 0.1 Lf when immunized along with alum generated antibody responses superior to those elicited by 10 Lf soluble antigen. Immunization with admixture of particles and alum generated two to three...Continue Reading

Citations

Jul 14, 2010·Expert Review of Vaccines·Mariana IngolottiDavid B Weiner
May 11, 2011·International Journal of Pharmaceutics·Aj BaxendaleL Illum
May 27, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Vibhu KanchanAmulya K Panda
Jun 21, 2020·Vaccines·Céline LemoineAnita Milicic
Oct 28, 2019·Bioscience Reports·Vaishnavi U WarrierRajesh Kumar Gupta

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