Immunogenicity and protective efficacy of recombinant Campylobacter jejuni flagellum-secreted proteins in mice.

Infection and Immunity
Shahida BaqarPatricia Guerry

Abstract

Immunogenicity and protective efficacy of three Campylobacter jejuni flagellum-secreted proteins, FlaC, FspA1, and FspA2, were compared by use of a mouse model. Mice were immunized intranasally with each protein with or without LTR192G as the adjuvant and challenged intranasally with C. jejuni 81-176 or CG8486. All three proteins were immunogenic, although FspA1 induced the highest levels of serum immunoglobulin G (IgG) and fecal IgA. Although immunogenic, FlaC provided only 18% protection against disease from C. jejuni 81-176. Immunization with FspA1 resulted in 57.8% protection without adjuvant or 63.8% protection with adjuvant against homologous challenge with 81-176. Alternatively, immunization with FspA2 provided 38.4% (without adjuvant) or 47.2% (with adjuvant) protection against disease from homologous challenge with CG8486. In contrast to FspA2, FspA1 provided some heterologous protection against C. jejuni CG8486 when delivered with (31.2%) or without (44.8%) LTR192G. These results suggest that FspA1 may be a good subunit vaccine candidate against C. jejuni disease.

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Citations

Jun 12, 2013·Veterinary Microbiology·Qiangde DuanGuoqiang Zhu
Jul 12, 2012·Foodborne Pathogens and Disease·Maojun ZhangJianzhong Zhang
Aug 24, 2010·Applied and Environmental Microbiology·C P A de HaanM L Hänninen
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Feb 24, 2012·Journal of Basic Microbiology·Qiangde DuanGuoqiang Zhu
Jan 25, 2011·Microbial Biotechnology·Byeonghwa JeonQijing Zhang
Sep 2, 2005·Vaccine·Donata R SizemoreKevin P Killeen
Apr 29, 2009·Expert Review of Vaccines·Elzbieta Katarzyna Jagusztyn-KrynickaAgnieszka Wyszyńska

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