Immunogenicity and Protective Efficacy of Radiation-Attenuated and Chemo-Attenuated PfSPZ Vaccines in Equatoguinean Adults.

The American Journal of Tropical Medicine and Hygiene
Said JongoStephen L Hoffman

Abstract

Plasmodium falciparum sporozoite (PfSPZ) Vaccine (radiation-attenuated, aseptic, purified, cryopreserved PfSPZ) and PfSPZ-CVac (infectious, aseptic, purified, cryopreserved PfSPZ administered to subjects taking weekly chloroquine chemoprophylaxis) have shown vaccine efficacies (VEs) of 100% against homologous controlled human malaria infection (CHMI) in nonimmune adults. Plasmodium falciparum sporozoite-CVac has never been assessed against CHMI in African vaccinees. We assessed the safety, immunogenicity, and VE against homologous CHMI of three doses of 2.7 × 106 PfSPZ of PfSPZ Vaccine at 8-week intervals and three doses of 1.0 × 105 PfSPZ of PfSPZ-CVac at 4-week intervals with each arm randomized, double-blind, placebo-controlled, and conducted in parallel. There were no differences in solicited adverse events between vaccinees and normal saline controls, or between PfSPZ Vaccine and PfSPZ-CVac recipients during the 6 days after administration of investigational product. However, from days 7-13, PfSPZ-CVac recipients had significantly more AEs, probably because of Pf parasitemia. Antibody responses were 2.9 times higher in PfSPZ Vaccine recipients than PfSPZ-CVac recipients at time of CHMI. Vaccine efficacy at a median of 14 w...Continue Reading

References

Feb 16, 2000·Transactions of the Royal Society of Tropical Medicine and Hygiene·G SnounouS Viriyakosol
Jul 31, 2009·The New England Journal of Medicine·Meta RoestenbergRobert Sauerwein
Feb 23, 2012·PloS One·Walter R Weiss, Chengyong George Jiang
Nov 15, 2012·The American Journal of Tropical Medicine and Hygiene·Meta RoestenbergStephen L Hoffman
Jul 30, 2014·The American Journal of Tropical Medicine and Hygiene·Seif ShekalagheStephen L Hoffman
Oct 16, 2015·Vaccine·Thomas L RichieStephen L Hoffman
May 10, 2016·Nature Medicine·Andrew S IshizukaRobert A Seder
Jan 18, 2017·JCI Insight·Judith E EpsteinStephen L Hoffman
Feb 16, 2017·Nature·Benjamin MordmüllerPeter G Kremsner
Feb 23, 2017·Proceedings of the National Academy of Sciences of the United States of America·Kirsten E LykeRobert A Seder
Dec 21, 2017·The American Journal of Tropical Medicine and Hygiene·Bertrand LellPeter G Kremsner
Dec 19, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jean Claude Dejon-AgobeBenjamin Mordmüller
Aug 14, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jane AchanUmberto D'Alessandro
Aug 17, 2019·The Journal of Infectious Diseases·Matthew B LaurensStephen L Hoffman
Sep 13, 2019·Lancet·Richard G A FeachemWinnie Mpanju-Shumbusho
Sep 13, 2019·Lancet·Tedros Adhanom Ghebreyesus
Dec 7, 2019·Tropical Medicine & International Health : TM & IH·Wolfram G MetzgerPeter G Kremsner
Sep 14, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kirsten E LykeUNKNOWN Warfighter II Study Team

❮ Previous
Next ❯

Citations

Mar 20, 2021·Risk Management and Healthcare Policy·Navneet AroraAshok K Pannu
Jun 25, 2021·Parasitology International·Arturo Reyes-Sandoval
Aug 5, 2021·Human Vaccines & Immunotherapeutics·Matthew B Laurens

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
ELISA

Clinical Trials Mentioned

NCT02859350
NCT02663700
NCT03952650

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.