Immunogenicity and reactogenicity of a single dose of a diphtheria--tetanus--acellular pertussis component vaccine (DTaP) compared to a diphtheria--tetanus toxoid (Td) and a diphtheria toxoid vaccine (d) in adults

Vaccine
I BartelsUlrich Heininger

Abstract

We compared immunogenicity and reactogenicity of a single dose of DTaP vaccine (containing tetanus and diphtheria toxoids and four acellular pertussis antigens) with conventional Td- or d-vaccines in 180 German adults. Antibody values against diphtheria and tetanus toxin and against the pertussis antigens fimbriae (FIM), filamentous hemagglutinin (FHA) and pertussis toxin (PT) were measured in pre- and post-immunization sera. Reactogenicity was determined by a patient diary card. Pre-immunization antibody values against diphtheria toxin were low in all three vaccine groups. After immunization, > or = 80% of the vaccinees in all three groups were fully protected (> or = 0.1 IU/ml), but geometric mean values were significantly higher in DTaP recipients compared to Td or d recipients (1.65 vs. 0.44 and 0.48, respectively; both P < 0.05). Pre-immunization antibody values against tetanus toxin were high in all three groups, and after immunization 100% of the vaccinees were protected (> or = 0.1 IU/ml). Furthermore, substantial antibody responses against pertussis antigens were elicited in DTaP recipients with geometric mean rises of 22.5, 4.1 and 7.5 for antibodies against FHA, fimbriae and PT, respectively. All three vaccines were ...Continue Reading

References

Oct 1, 1977·Lancet·E Rabo
Dec 1, 1992·The Journal of Infectious Diseases·J A EnglundL Barreto
Feb 1, 1987·European Journal of Clinical Microbiology·M GranströmY Sato
Nov 18, 1995·Lancet·C H Wirsing von KönigH J Schmitt
May 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J D CherryK Stehr
Jan 6, 1993·JAMA : the Journal of the American Medical Association·K M EdwardsJ Hackell
Oct 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S Schmitt-GrohéK Stehr
Mar 7, 1997·Deutsche medizinische Wochenschrift·H M HasselhornF Hofmann
Aug 14, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J B Robbins

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Citations

Dec 7, 2002·The Lancet Infectious Diseases·C H Wirsing von KönigN Guiso
May 7, 2005·The Pediatric Infectious Disease Journal·Kevin ForsythStanley Plotkin
Jul 22, 2008·Vaccine·Roy RobertsDaniela Hozbor
Jan 19, 2006·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Brian R BoulayElizabeth A Talbot
Jan 16, 2010·Journal of Travel Medicine·Lin H ChenMary E Wilson
Apr 28, 2018·MMWR. Recommendations and Reports : Morbidity and Mortality Weekly Report. Recommendations and Reports·Jennifer L LiangThomas A Clark

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