Immunogenicity and safety of an HIV-1 lipopeptide vaccine in healthy adults: a phase 2 placebo-controlled ANRS trial

AIDS
Dominique Salmon-CeronANRS VAC18 trial group

Abstract

French National Agency for Research on AIDS and Viral Hepatitis's HIV-LIPO-5 vaccine includes five HIV-1 peptides, containing multiple CD8 and CD4 T-cell epitopes and coupled to a palmitoyl tail. Whether HIV-LIPO-5 immunogenicity varies with the dose is unknown. HIV-negative volunteers were randomized to receive HIV-LIPO-5 vaccine at 50 microg/lipopeptide (N = 32), 150 microg/lipopeptide (N = 32), 500 microg/lipopeptide (N = 33) or placebo (N = 34) at weeks 0, 4, 12 and 24. HIV-1-specific CD8 (interferon-gamma ELISpot on peripheral blood mononuclear cells cultured for 12 days) and CD4 responses (peripheral blood mononuclear cell lymphoproliferation) were assessed at baseline, after each injection and at week 48. Local reactions were dose-dependent but no differences in systemic reactions appeared between groups. Sustained (at least on two separate occasions) CD8 response rates to at least one given HIV-1 pool were obtained in 22 of 32 (69%), 21 of 33 (64%) and 21 of 34 (62%) individuals for LIPO-5 50, 150 and 500 groups, respectively (P < or = 0.0001 for all comparisons to the placebo). Cumulative CD4 response rates were obtained in 15 of 32 (47%), 18 of 33 (55%) and 15 of 34 (44%) individuals (P < 0.0001 for all comparisons to...Continue Reading

References

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Citations

Jun 14, 2013·AIDS·Laura RichertUNKNOWN ANRS Vaccine Network/Vaccine Research Institute
Apr 1, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kuan-Yin ShenShih-Jen Liu
Dec 4, 2012·Microbial Pathogenesis·Dorothee DulucSangkon Oh
Nov 26, 2010·Journal of Immunological Methods·Amanda CobbJacques Banchereau
Jan 5, 2013·The Open AIDS Journal·Missa P SanouJanet K Yamamoto
Jan 13, 2018·Current Opinion in HIV and AIDS·Nabila Seddiki, Yves Lévy
May 3, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Florence Anne CastelliBernard Maillère
Sep 8, 2017·Expert Review of Vaccines·Mathieu SurenaudJean-Daniel Lelièvre
Oct 7, 2017·Journal of Chemical Technology and Biotechnology·Nanxi WangJiantao Guo
Dec 10, 2019·NPJ Vaccines·Elodie PetitdidierRachel Bras-Gonçalves
Jun 19, 2021·Molecular Therapy Oncolytics·Dorian A StolkYvette van Kooyk

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