Immunogenicity and Safety of Influenza Vaccine in Inflammatory Bowel Disease Patients Treated or not with Immunomodulators and/or Biologics: A Two-year Prospective Study

Journal of Crohn's & Colitis
Odile LaunayMICIVAX Study Group

Abstract

Data on the efficacy and safety of seasonal influenza vaccines in patients with inflammatory bowel disease (IBD) remain scarce. The aim of the study was to evaluate the impact of immunosuppressive (IS) therapeutics on serological response to 2-year influenza vaccination in IBD adults. A multicentre prospective study performed in 255 IBD adults (18-64 years) receiving the trivalent influenza vaccine in the years 2009-2010 and 2010-2011. Haemagglutination inhibition (HI) titres were assessed before and 3 weeks and 6 months after vaccination. At inclusion, 31 patients were receiving no IS treatment (Group A), 77 were receiving IS treatment without anti-TNF (Group B) and 117 were receiving anti-tumour necrosis factor (TNF) treatment with or without IS treatment (Group C). Three weeks after the first vaccination, rates of seroprotection were 77, 75 and 66% for strain A/H1N12007 (p = 0.35), 77, 68 and 52% for strain A/H3N2 (p = 0.014) and 97, 96 and 95% for strain B (p = 0.99) in Groups A, B and C, respectively. Seroconversion rates for A/H1N12007 (67, 64 and 54%; p = 0.28), A/H3N2 (63, 50 and 41%; p = 0.074) and strain B (63, 76 and 60%; p = 0.078) were not significantly different among treatment groups. At 6 months after vaccinatio...Continue Reading

References

Jul 13, 2001·Infectious Disease Clinics of North America·E BouzaP Muñoz
Jun 18, 2003·Annals of the Rheumatic Diseases·M J BridgesC Heycock
Oct 9, 2004·Inflammatory Bowel Diseases·Bruce E SandsWalter Orenstein
Jul 5, 2006·The American Journal of Gastroenterology·Gil Y MelmedEric A Vasiliauskas
May 15, 2007·Lancet·Daniel C Baumgart, Simon R Carding
May 15, 2007·Lancet·Daniel C Baumgart, William J Sandborn
Jun 5, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Petar MamulaRobert N Baldassano
Feb 26, 2008·Gastroenterology·Murat TorunerLaurence J Egan
Nov 22, 2008·Autoimmunity Reviews·Ennio Giulio FavalliAntonio Marchesoni
Jan 29, 2009·The American Journal of Gastroenterology·Ying LuAthos Bousvaros
Feb 20, 2009·JAMA : the Journal of the American Medical Association·Anja StrangfeldAngela Zink
Jun 2, 2009·Rheumatic Diseases Clinics of North America·Emilio Martin-Mola, Alejandro Balsa
Jan 29, 2011·Gut·Jean-François RahierUNKNOWN European Crohn's and Colitis Organisation (ECCO)
Apr 8, 2011·Inflammatory Bowel Diseases·Jennifer C C deBruynIwona Wrobel
Jan 15, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lorry G Rubin Infectious Diseases Society of America
Mar 13, 2014·Journal of Crohn's & Colitis·J F RahierUNKNOWN European Crohn's and Colitis Organisation (ECCO)

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Citations

Sep 20, 2018·Expert Review of Clinical Pharmacology·Maria GerosaCecilia Beatrice Chighizola
Oct 3, 2018·Expert Review of Gastroenterology & Hepatology·Zachary A BormanJean-Frédéric Colombel
Nov 23, 2018·Journal of Cutaneous Medicine and Surgery·Kim A PappJohn Wade
Aug 4, 2020·The American Journal of Gastroenterology·Freddy CalderaFrancis A Farraye
Sep 11, 2019·Inflammatory Bowel Diseases·Gaurav Syal, Gil Y Melmed
Apr 2, 2020·Inflammatory Bowel Diseases·Freddy CalderaFrancis A Farraye
Oct 1, 2020·Digestive Diseases and Sciences·Ryan SmithFreddy Caldera
Jan 29, 2021·The Lancet. Gastroenterology & Hepatology·James L AlexanderUNKNOWN Inflammatory Bowel Disease section of the British Society of Gastroenterology and the the Inflammatory Bowel Disease Clinica
Mar 16, 2021·Journal of Crohn's & Colitis·Judith WellensSerre-Yu Wong
Jun 18, 2021·Curēus·Mandi AbdelahadMichelle Demory Beckler
Aug 10, 2021·World Journal of Gastroenterology : WJG·Vincenzo CraviottoMariangela Allocca
Sep 3, 2021·Alimentary Pharmacology & Therapeutics·Jayne DohertyGlen A Doherty
Nov 1, 2021·Gastroenterology·Hadar Edelman-KlapperUNKNOWN REsponses to COVid-19 vaccinE IsRaeli IBD group [RECOVER]

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